Large FOV phase contrast imaging based on detuned configuration including acquisition and reconstruction techniques

Patent metadata

Field	Value
Publication number	US-10058300-B2
Application number	US-201615146923-A
Country	US
Kind code	B2
Filing date	May 5, 2016
Priority date	Dec 30, 2013
Publication date	Aug 28, 2018
Grant date	Aug 28, 2018

Abstract

Embodiments of methods and apparatus are disclosed for obtaining a phase-contrast digital imaging system and methods for same that can include an x-ray source for radiographic imaging; a beam shaping assembly, an x-ray grating interferometer including a phase grating and an analyzer grating; and an x-ray detector; where the source grating, the phase grating, and the analyzer grating are detuned and a plurality of uncorrelated reference images are obtained for use in imaging processing with the detuned system.

First claim

What is claimed is:

1. A method, comprising:
providing an x-ray source for radiographic imaging;
providing a beam shaping assembly comprising a source grating G0;
providing an x-ray grating interferometer comprising a phase grating G1, and an analyzer grating G2;
providing an x-ray detector;
aligning the source grating G0, the phase grating G1, the analyzer grating G2, and the x-ray detector;
offsetting a pitch of the analyzer grating G2 relative to a pitch of an interference pattern produced by the phase grating G1 at a prescribed distance from the phase grating G1 to generate a repeating fringe pattern;
repeatedly exposing an object using the x-ray source while simultaneously moving at least the x-ray source and the source grating G0, relative to at least one cycle of the fringe pattern, while holding the object in a stationary position to generate a set of image data; and
capturing a plurality of images of the object by the x-ray detector.

2. The method of claim 1 , further comprising simultaneously moving the phase grating G1, the analyzer grating G2, and the x-ray detector together with the x-ray source and the beam shaping assembly.

3. The method of claim 2 further comprising transforming the set of image data to form a transformed image data set where the fringe pattern moves across the stationary object.

4. The method of claim 3 , further comprising:
transforming a set of reference images equal in number or more to the set of transformed image data set; and
Fourier reconstructing the transformed image data set and the transformed reference images to at least one of extract transmission, dark-field, differential phase contrast, and integrated phase images of the object.

5. The method of claim 1 , further comprising collecting the reference images prior to or after the step of exposing the object, or storing the reference images in advance of the step of exposing the object.

6. The method of claim 1 , wherein the beam shaping assembly comprises a beam limiting apparatus and the source grating G0 or a microfocus X-ray source.

7. The method of claim 2 , further comprising stepping the source, gratings, and detector.

8. The method of claim 7 , further comprising setting a period of the fringe pattern to make the size of an imaging step greater than or equal to a pixel pitch of the x-ray detector or a fraction of the pixel pitch of the x-ray detector.

9. A method, comprising:
providing an x-ray source for radiographic imaging;
providing a beam shaping assembly;
providing an x-ray grating interferometer comprising a phase grating G1, and an analyzer grating G2;
offsetting a pitch of the analyzer grating G2 relative to a pitch of an interference pattern produced by the phase grating G1 at a prescribed distance from the phase grating G1 to generate a fringe pattern;
repeatedly exposing an object using the x-ray source while simultaneously moving the x-ray source, the beam shaping assembly, the phase grating G1, and the analyzer grating G2 relative to at least one cycle of the fringe pattern to generate a set of image data; and
capturing a plurality of reference images using an x-ray detector,
wherein the step of repeatedly exposing the object comprises holding the object stationary while stepping the x-ray source, the beam shaping assembly, the phase grating G1, and the analyzer grating G2 with a step size equal to np x /M, and wherein n is an integer number (1, 2, 3, . . . ), p x is a detector's pixel pitch and M is an image magnification.

10. A method, comprising:
providing an x-ray source for radiographic imaging;
providing a beam shaping assembly;
providing an x-ray grating interferometer comprising a phase grating G1, and an analyzer grating G2;
offsetting a pitch of the analyzer grating G2 relative to a pitch of an interference pattern produced by the phase grating G1 at a prescribed distance from the phase grating G1 to generate a fringe pattern;
repeatedly exposing an object using the x-ray source while simultaneously moving the x-ray source, the beam shaping assembly, the phase grating G1, and the analyzer grating G2 relative to at least one cycle of the fringe pattern to generate a set of image data; and
capturing a plurality of reference images using an x-ray detector,
wherein the x-ray source, the beam shaping assembly, the grating interferometer, and the detector are attached to a rigid arm to move together simultaneously, the rigid arm is moved to perform a single field-of-view scan by exposing X sequential positions of the x-ray detector to obtain X raw images, a distance between the X sequential positions is equivalent to np x /M, and wherein n is an integer number (1, 2, 3, . . . ), p x is a detector's pixel pitch and M is an image magnification.

11. The method of claim 10 , further comprising tiling a configuration of interferometers for an object larger than a field of view for each tiled interferometer.

12. The method of claim 10 , wherein exposing an object larger than a field of view of the interferometer comprises:
performing multiple imaging of the object using only one x-ray grating interferometer, including the interferometer scanning the object at a first position and scanning the object at a second position; and
stitching together an image of the object using the interferometer scans of the object at the first position and at the second position.

13. A digital radiographic (DR) phase-contrast imaging (PCI) system comprising:
an x-ray source;
a beam shaping assembly comprising a source grating G0;
an x-ray grating interferometer comprising,
a phase grating G1, and
an analyzer grating G2; and
an x-ray detector;

wherein a pitch and a position of the analyzer grating G2 relative to a pitch of an interference pattern produced by the phase grating GI produce a fringe pattern over a width of the analyzer grating G2, the relative position of the x-ray source, the source grating G0, the phase grating G1, the analyzer grating G2, and the x-ray detector is fixed for an image scan of an imaging area of the DR PCI system,
the imaging area is configured to remain stationary relative to a movement of the fringe pattern across the imaging area during the image scan, and wherein the x-ray detector is configured to generate a plurality of uncorrelated reference images.

14. The system of claim 13 , wherein the system is configured to move the source, the beam shaping assembly, and the grating interferometer, while the imaging area is repeatedly exposed using the x-ray source, to generate a set of image data.

15. The system of claim 13 , wherein the system is configured to shift the set of image data to form a transformed image data set, and to fourier reconstruct the transformed image data set and a set of the uncorrelated reference images at least equal in number to the set of transformed image data set to extract at least one of transmission, dark-field, differential phase contrast, and integrated phase images of the object.

16. The system of claim 13 , wherein the system is configured to collect reference images prior to or after the object scan, or to store the reference images in advance.

17. The system of claim 13 , wherein the system is configured to produce the fringe pattern by having the pitch of the analyzer grating G2 being unequal to the pitch of an interference pattern produced by the phase grating G1 at a position of the analyzer grating G2.

18. The system of claim 13 , wherein the system is configured to produce the fringe pattern by having the position of the analyzer grating G2 offset

Assignees

• Carestream Health Inc

Inventors

• Baturin Pavlo
• Shafer Mark E

Classifications

• G01N2223/427

  stepped imaging (selected area of sample is changed) · CPC title

• A61B6/484 Primary

  involving phase contrast X-ray imaging · CPC title

• G01N23/20075

  by measuring interferences of X-rays, e.g. Borrmann effect · CPC title

• A61B6/06

  Diaphragms · CPC title

• G03H5/00

  Holographic processes or apparatus using particles or using waves other than those covered by groups G03H1/00 or G03H3/00 for obtaining holograms; Processes or apparatus for obtaining an optical image from them (G03H1/22 takes precedence; construction of electron microscopes H01J37/26; {investigating or analysing materials by the use of microwaves G01N22/00, by the use of particles wave or X-rays G01N23/00, G21K7/00}) · CPC title