Process for producing cellulose derivatives of high bulk density, good flowability and/or dispersibility in cold water as well as low solution color

Patent metadata

Field	Value
Publication number	US-10053519-B2
Application number	US-201615096704-A
Country	US
Kind code	B2
Filing date	May 4, 2016
Priority date	Sep 25, 2012
Publication date	Aug 21, 2018
Grant date	Aug 21, 2018

Abstract

The obtained particulate cellulose derivative has a high untapped bulk density, a good flowability and a low color intensity.

First claim

What is claimed is:

1. A method of improving the flowability and/or the cold water dispersibility of a particulate cellulose derivative comprising the steps of
A) providing a moist cellulose derivative having a moisture content of from 25 to 95 percent, based on the total weight of the moist cellulose derivative, with the proviso that no substantial amount of surface-treatment additive is added to the cellulose derivative,
B) grinding and partially drying the moist cellulose derivative in a gas-swept impact mill wherein a gas fed into the impact mill has a temperature of 100° C. or less;
C) contacting the ground and partially dried cellulose derivative with an additional amount of a drying gas outside the gas-swept impact mill, wherein the additional amount of drying gas outside the gas-swept impact mill has a higher temperature than the gas fed into the impact mill; and
D) subjecting the cellulose derivative to partial depolymerization after having contacted the cellulose derivative with the drying gas in step C)
to produce the particulate cellulose derivative,

wherein the produced particulate cellulose derivative has
i) an untapped bulk density of at least 370 g/l,
ii) a Carr Index of 16 or less;
iii) a viscosity of from 1.2 to 200 mPa·s, measured as a 2 weight-% solution in water at 20° C. according to DIN 51562-1:1999-01; and
iv) a color of not more than 35 American Public Health Association (APHA) color units, determined as a 2 weight-% solution in water at 20° C. according to ASTM D1209-05(2011).

2. A particulate cellulose derivative having
i) an untapped bulk density of at least 370 g/l,
ii) a Carr Index of 16 or less;
iii) a viscosity of from 1.2 to 200 mPa·s, measured as a 2 weight-% solution in water at 20° C. according to DIN 51562-1:1999-01; and
iv) a color of not more than 35 American Public Health Association (APHA) color units, determined as a 2 weight-% solution in water at 20° C. according to ASTM D1209-05(2011).

3. The particulate cellulose derivative of claim 2 having a median Equivalent Projected Circle Diameter (EQPC) of at least 50 micrometers.

4. An aqueous composition produced by blending water, the particulate cellulose derivative of claim 2 and one or more optional additives.

5. A process for the manufacture of capsules comprising the step of contacting the aqueous composition of claim 4 with dipping pins.

6. A process for coating a dosage form comprising the step of contacting the aqueous composition of claim 4 with the dosage form.

7. The particulate cellulose derivative of claim 2 being one of an alkyl cellulose, hydroxyalkyl cellulose or hydroxyalkyl alkylcellulose.

8. The particulate cellulose derivative of claim 2 being hydroxypropyl methylcellulose.

9. The particulate cellulose derivative of claim 2 having an untapped bulk density of at least 430 g/l.

10. The particulate cellulose derivative of claim 2 having a median Length of Fiber (LEFI) of from 50 to 600 micrometers.

11. The particulate cellulose derivative of claim 2 having a median Length of Fiber (LEFI) of from 100 to 400 micrometers.

12. The particulate cellulose derivative of claim 2 having a median Equivalent Projected Circle Diameter (EQPC) of from 100 to 300 micrometers.

Assignees

• Dow Global Technologies Llc

Inventors

• Goerlach-Doht Yvonne M
• Hermanns Juergen
• Hoelzer Bettina

Classifications

• C08J3/124 Primary

  Treatment for improving the free-flowing characteristics · CPC title

• A61K9/4891

  Coated capsules; Multilayered drug free capsule shells (with drug coating for immediate release A61K9/4808; osmotic devices A61K9/0004) · CPC title

• Y10T428/2982

  Particulate matter [e.g., sphere, flake, etc.] · CPC title

• C08L1/08

  Cellulose derivatives · CPC title

• C09D101/26

  Cellulose ethers · CPC title