Injectable, biodegradable bone cements and methods of making and using same

Patent metadata

Field	Value
Publication number	US-10052402-B2
Application number	US-201615078391-A
Country	US
Kind code	B2
Filing date	Mar 23, 2016
Priority date	Jan 31, 2012
Publication date	Aug 21, 2018
Grant date	Aug 21, 2018

Abstract

Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.

First claim

What is claimed is:

1. A method of making a bone cement, the method comprising:
mixing a basic source of magnesium with a setting solution comprising H 3 PO 4 to form a bone cement paste;
irradiating the bone cement paste with electromagnetic radiation to form dry powders, wherein the dry powders comprise newberyite; and
mixing the dry powders with a silica sol as a setting solution to form a radiation-assisted bone cement paste that sets into a hardened mass.

2. The method of claim 1 , wherein the bone cement paste comprises a biopolymer.

3. The method of claim 2 , wherein the biopolymer comprises chitosan.

4. The method of claim 1 , further comprising crushing the dry powders.

5. The method of claim 2 , wherein the biopolymer is surface-phosphorylated.

6. The method of claim 1 wherein the basic source of magnesium comprises Mg(OH) 2 .

7. The method of claim 1 , further comprising injecting the radiation-assisted bone cement paste into an anatomical location, and then allowing the radiation-assisted bone cement paste to set into a hardened mass.

8. The method of claim 1 , wherein the setting process gives off minimal heat so as to not cause necrosis to living tissue surrounding the bone cement.

9. The method of claim 1 , further comprising adding one or more additives to the dry powders.

10. A method of making a bone cement, the method comprising:
irradiating a bone cement paste comprising magnesium phosphate with electromagnetic radiation to form dry powders, wherein the dry powders comprise newberyite: and
mixing the dry powders with a non-aqueous extender to produce a pre-mixed putty,
wherein the pre-mixed putty further comprises silica, and
wherein the pre-mixed putty is capable of producing a bone cement paste that sets into a hardened mass upon contact with water.

11. The method of claim 10 , further comprising mixing the pre-mixed putty with water to produce a cement paste that sets into a hardened mass.

12. The method of claim 10 , wherein the non-aqueous extender comprises glycerine or propylene glycol.

13. The method of claim 10 , wherein the bone cement paste comprises a biopolymer.

14. The method of claim 10 , wherein the bone cement paste is made by an acid-base reaction.

15. The method of claim 10 , further comprising adding one or more additives to the dry powders.

16. The method of claim 10 , further comprising crushing the dry powders.

17. The method of claim 1 , wherein the radiation-assisted bone cement paste further comprises strontium.

18. The method of claim 1 , wherein the hardened mass is doped with strontium.

Assignees

• Univ Toledo

Inventors

• Bhaduri Sarit B
• Zhou Huan
• Agarwal Anand K
• Goel Vijay K

Classifications

• A61K6/898

  Polysaccharides · CPC title

• A61K6/864

  Phosphate cements (apatite A61K6/838) · CPC title

• A61K6/74

  comprising phosphorus-containing compounds · CPC title

• A61L24/0084

  containing fillers of phosphorus-containing inorganic compounds, e.g. apatite · CPC title

• A61L2430/12

  for dental implants or prostheses · CPC title