System and method for early detection of alzheimers by detecting amyloid-beta using orbital angular momentum
US-9784724-B2 · Oct 10, 2017 · US
US10048202B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10048202-B2 |
| Application number | US-201715677552-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 15, 2017 |
| Priority date | Jul 24, 2014 |
| Publication date | Aug 14, 2018 |
| Grant date | Aug 14, 2018 |
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An apparatus for identifying a material within a sample comprising signal generation circuitry generates a first signal including a first orbital angular momentum (OAM) signature and applies the first signal to the sample. A detector receives the first signal after the first signal passes through the sample and identifies the material within the sample based on a detected second orbital angular momentum caused by an interaction of the first signal with chiral molecules within the sample.
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What is claimed is: 1. An apparatus for identifying a material within a sample, comprising: signal generation circuitry for generating a first signal including a first orbital angular momentum (OAM) signature and applying the first signal to the sample; and a detector for receiving the first signal after the first signal passes through the sample and identifying the material within the sample based on a detected second orbital angular momentum signature caused by an interaction of the first signal with chiral molecules within the sample. 2. The apparatus of claim 1 , wherein ambient light scattering by the chiral molecules within the sample is not detected. 3. The apparatus of claim 1 , wherein the signal generation circuitry further comprises: a plane wave signal generator for generating a signal comprised of a plurality of plane waves; and a spatial light modulator for generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves. 4. The apparatus of claim 1 , wherein the signal generation circuitry further comprises: a plane wave signal generator for generating a signal comprised of a plurality of plane waves; and an amplitude mask for generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves. 5. The apparatus of claim 1 , wherein the signal generation circuitry further comprises: a plane wave signal generator for generating a signal comprised of a plurality of plane waves; and a phase mask for generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves. 6. The apparatus of claim 1 , wherein the signal generation circuitry further comprises: a plane wave signal generator for generating a signal comprised of a plurality of plane waves; and a digital light processor for generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves. 7. The apparatus of claim 1 , wherein the signal generation circuitry further comprises: a plane wave signal generator for generating a signal comprised of a plurality of plane waves; and orbital angular momentum generation circuitry for generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves, wherein the orbital angular momentum circuitry further comprises at least one hologram for applying the first orbital angular momentum signature to the signal comprised of the plurality of plane waves. 8. The apparatus of claim 7 , wherein the detector further includes circuitry for determining a phase of the first signal after the first signal passes through the sample, wherein the circuitry determines the phase by interfering the first signal having the second orbital angular momentum signature therein with an interference signal having the plane waves therein. 9. The apparatus of claim 1 , wherein the detector identifies the material within the sample based on a detected amplitude measurement and phase measurement of the second orbital angular momentum signature caused by an interaction of the first signal with the chiral molecules within the sample. 10. A method for identifying a material within a sample, comprising: generating a first signal including a first orbital angular momentum (OAM) signature therein; applying the first signal to the sample; receiving the first signal after the first signal passes through the sample; and identifying the material within the sample based on a detected second orbital angular momentum signature caused by an interaction of the first signal with chiral molecules within the sample. 11. The method of claim 10 , wherein ambient light scattering by the chiral molecules within the sample is not detected. 12. The method of claim 10 , wherein the step of generating further comprises: generating a signal comprised of a plurality of plane waves; and generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves using a spatial light modulator. 13. The method of claim 10 , wherein the step of generating further comprises: generating a signal comprised of a plurality of plane waves; and generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves using an amplitude mask. 14. The method of claim 10 , wherein the step of generating further comprises: generating a signal comprised of a plurality of plane waves; and generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves using a phase mask. 15. The method of claim 10 , wherein the step of generating further comprises: generating a signal comprised of a plurality of plane waves; and generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves using a digital light processor. 16. The method of claim 10 , wherein the step of generating further comprises: generating a signal comprised of a plurality of plane waves; and generating the first signal having the first orbital angular momentum signature applied thereto responsive to receipt of the signal comprised of the plurality of plane waves by applying the first orbital angular momentum signature to the signal comprised of the plurality of plane waves. 17. The method of claim 16 , wherein the step of identifying further includes: determining a phase of the first signal after the first signal passes through the sample; and interfering the first signal having the second orbital angular momentum signature therein with an interference signal having the plane waves therein to determine the phase of the first signal after the first signal passes through the sample. 18. The method of claim 10 , wherein the step of identifying further comprises: detecting an amplitude measurement and phase measurement of the second orbital angular momentum signature caused by an interaction of the first signal with the chiral molecules in the sample; and identifying the material within the sample based on the detected amplitude measurement and phase measurement of the second orbital angular momentum signature. 19. A detector for identifying a material within a sample, comprising: an input interface for receiving a first signal having an orbital angular momentum (OAM) signature applied thereto caused by passing through the sample; detection circuitry for detecting the orbital angular momentum signature within the first signal and identifying the material within the sample based on the detected orbital angular momentum signature caused by an interaction of the first signal with chiral molecules within the sample as the first signal passes through the sample. 20. The detector of claim 19 , wherein the detection circuitry identifies the material within the sample based on a detected amplitude measurement and phase measurement of the orbital angular mom
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