Cyclic dinucleotides useful for the treatment of inter alia cancer

Patent metadata

Field	Value
Publication number	US-10047115-B2
Application number	US-201615543007-A
Country	US
Kind code	B2
Filing date	Jan 27, 2016
Priority date	Jan 29, 2015
Publication date	Aug 14, 2018
Grant date	Aug 14, 2018

Abstract

A compound of formula (I)

or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

First claim

The invention claimed is:

1. A compound of formula (I)

wherein
R 1 is OH and R 2 is NH 2 or R 1 is NH 2 and R 2 is H;
R 3 is OH and R 4 is NH 2 or R 3 is NH 2 and R 4 is H;
One of R 5 and R 6 is F, the other is F or OH,
or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof according to claim 1 and one or more of pharmaceutically acceptable excipients.

3. A combination comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof according to claim 1 and at least one further therapeutic agent.

4. A compound of claim 1 which is:

or a pharmaceutically acceptable salt thereof.

5. A compound of claim 4 which is:

6. A pharmaceutically acceptable salt of a compound of claim 4 which is:

7. A compound of claim 1 which is:

or a pharmaceutically acceptable salt thereof.

8. A compound of claim 7 which is:

9. A pharmaceutically acceptable salt of a compound of claim 7 which is:

Assignees

• Glaxosmithkline Ip Dev Ltd

Inventors

• Biggadike Keith
• Champigny Aurelie Cecile
• Coe Diane Mary
• Needham Deborah
• Tape Daniel Terence

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title