C-Met Modulators and Methods of Use
US-2015376133-A1 · Dec 31, 2015 · US
Compounds and methods for inhibiting vacuolar ATPase
US10047058B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10047058-B2 |
| Application number | US-201615384016-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 19, 2016 |
| Priority date | Dec 18, 2015 |
| Publication date | Aug 14, 2018 |
| Grant date | Aug 14, 2018 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
A compound of Formula II, is provided. R 1 , R 2 and R 3 are independently either hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino or hydroxyl. X is either F, Cl, Br, I or CN. Y is either N or CH. Compositions that include Formula II can be used to inhibit vacuolar H + ATPase.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound of Formula II, wherein R 1 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl, R 2 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl, R 3 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl, X is selected from the group consisting of F, Br, I and CN, and Y is N or CH. 2. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is F, and Y is N. 3. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is Br, and Y is N. 4. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is I, and Y is N. 5. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is CN, and Y is N. 6. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is F, and Y is CH. 7. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is Br, and Y is CH. 8. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is I, and Y is CH. 9. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is CN, and Y is CH. 10. A method of inhibiting vacuolar H + ATPase comprising treating vacuolar H + ATPase with a composition comprising a compound of Formula II, wherein R 1 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl, R 2 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl, R 3 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl, X is selected from the group consisting of F, Cl, Br, I and CN, and Y is N or CH. 11. A method of inhibiting vacuolar H + ATPase comprising treating vacuolar H + ATPase with a composition comprising the compound of claim 10 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is Cl, and Y is N. 12. The method of claim 10 , wherein a catalytic subunit A of the vacuolar H + ATPase is targeted. 13. The method of claim 11 , wherein a catalytic subunit A of the vacuolar H + ATPase is targeted.
Assignees
Inventors
Classifications
- C07D239/94Primary
Nitrogen atoms · CPC title
with aryl radicals attached to said nitrogen atoms · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US10047058B2 cover?
- A compound of Formula II, is provided. R 1 , R 2 and R 3 are independently either hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino or hydroxyl. X is either F, Cl, Br, I or CN. Y is either N or CH. Compositions that include Formula II can be used to inhibit vacuolar H + ATPase.
- Who is the assignee on this patent?
- Zhang Chao, Chen ying chu, Univ Southern California
- What technology area does this patent fall under?
- Primary CPC classification C07D239/94. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).