Stabilized Lactate Responsive Enzymes, Electrodes and Sensors, and Methods for Making and Using the Same
US-2016362716-A1 · Dec 15, 2016 · US
US10046099B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10046099-B2 |
| Application number | US-201514865583-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 25, 2015 |
| Priority date | Oct 22, 2012 |
| Publication date | Aug 14, 2018 |
| Grant date | Aug 14, 2018 |
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A system and method for determining a concentration of total chlorine in dialysis water are provided. The system comprises a main unit housing an iodide/water sample chamber and a reducing agent chamber. An electrode pair bridges the two chambers and generates tri-iodide proportional to the amount of total chlorine in the dialysis water. The electrode pair detects the amount of tri-iodide generated in proportion to the amount of active chloride in the dialysis water. The system is suitable for use in connection with, or for incorporation into, a water purification system for generating dialysis fluid, and may include a display that alerts the user to stop or prevent a hemodialysis treatment if the total chlorine level exceeds a predetermined level.
Opening claim text (preview).
What is claimed is: 1. A chlorine detector comprising: a first chamber in fluid communication with an iodide reservoir and a source of at least partially purified water; a second chamber in fluid communication with a reducing agent reservoir, wherein the first and second chambers are separated by a membrane that allows an electrical charge but not fluid to pass between the chambers; an electrode pair associated with a voltage source, wherein one electrode of the electrode pair is in contact with an interior of the first chamber and the other electrode of the electrode pair is in contact with an interior of the second chamber; and a control unit connected operably to the electrode pair, the control unit configured to (i) at one time cause the voltage source to apply a source voltage to the electrode pair and (ii) at a second time stop applying the source voltage to the electrode pair and instead monitor an electrical parameter through or across the electrode pair. 2. The chlorine detector of claim 1 , wherein at least one of the electrodes includes a metal selected from the group consisting of platinum, gold, stainless steel, copper, combinations thereof, and alloys thereof. 3. The chlorine detector of claim 1 , wherein at least one of the first and second chambers includes a tube. 4. The chlorine detector of claim 1 , wherein the first and second chambers both include tubes, and wherein the first chamber is disposed within a lumen of the second tube. 5. The chlorine detector of claim 1 , wherein at least one electrode of the electrode pair comprises a resistor. 6. The chlorine detector of claim 1 , wherein one electrode of the electrode pair is placed in electrical communication with a ground. 7. The chlorine detector of claim 1 comprising an agitator in contact with at least one of the first and second chambers. 8. The chlorine detector of claim 1 , wherein at least one of the first chamber, the iodide reservoir, or the reducing agent reservoir is in a replaceable cartridge or cassette form. 9. The chlorine detector of claim 1 comprising at least one pump and valve configured to pump deionized water into at least one of the first and second chambers. 10. The chlorine detector of claim 1 comprising at least one pump and valve configured to pull fluid from at least one of the first and second chambers to drain.
Water · CPC title
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