Antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and uses thereof
US-2015099298-A1 · Apr 9, 2015 · US
Nucleic acids and host cells expressing antibodies capable of binding to the coagulation factor XIa and uses thereof
US10040866B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10040866-B2 |
| Application number | US-201715691736-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 30, 2017 |
| Priority date | May 10, 2012 |
| Publication date | Aug 7, 2018 |
| Grant date | Aug 7, 2018 |
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- Title
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Abstract
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The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
First claim
Opening claim text (preview).
The invention claimed is: 1. A nucleic acid coding for an antibody capable of binding to coagulation Factor XIa comprising SEQ ID NO: 19 for the variable light chain domain and SEQ ID NO: 20 for the variable heavy chain domain. 2. A vector comprising the nucleic acid according to claim 1 . 3. A host cell comprising the vector of claim 2 . 4. A nucleic acid coding for an antibody capable of binding to coagulation Factor XIa comprising CDRH1 as SEQ ID NO: 21, CDRH2 as SEQ ID NO: 22, and CDRH3 as SEQ ID NO: 23; CDRL1 as SEQ ID NO: 24, CDRL2 as SEQ ID NO: 25, and CDRL3 as SEQ ID NO: 26. 5. A vector comprising the nucleic acid according to claim 4 . 6. A host cell comprising the vector of claim 5 . 7. A nucleic acid coding for an antibody capable of binding to coagulation Factor XIa comprising SEQ ID NO: 27 for the variable light chain domain and SEQ ID NO: 20 for the variable heavy chain domain. 8. A vector comprising the nucleic acid according to claim 7 . 9. A host cell comprising the vector of claim 8 . 10. A nucleic acid coding for an antibody capable of binding to coagulation Factor XIa comprising CDRH1 as SEQ ID NO: 21, CDRH2 as SEQ ID NO: 22, and CDRH3 as SEQ ID NO: 23; CDRL1 as SEQ ID NO: 24, CDRL2 as SEQ ID NO: 25, and CDRL3 as SEQ ID NO: 28. 11. A vector comprising the nucleic acid according to claim 10 . 12. A host cell comprising the vector of claim 11 .
Assignees
Inventors
Classifications
Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title
comprising antibodies · CPC title
Complementarity determining region [CDR] · CPC title
variable (Fv) region, i.e. VH and/or VL · CPC title
containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered · CPC title
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Frequently asked questions
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- What does patent US10040866B2 cover?
- The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
- Who is the assignee on this patent?
- Bayer Pharma AG
- What technology area does this patent fall under?
- Primary CPC classification C07K16/36. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 07 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).