Inhibitors of influenza viruses replication

Patent metadata

Field	Value
Publication number	US-10039762-B2
Application number	US-201715718186-A
Country	US
Kind code	B2
Filing date	Sep 28, 2017
Priority date	Jun 17, 2009
Publication date	Aug 7, 2018
Grant date	Aug 7, 2018

Abstract

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I):

or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

First claim

What is claimed is:

1. A method preparing a compound of formula 1070:

or a pharmaceutically acceptable salt thereof, comprising the steps of:
i) reacting a compound having the formula:

with

to form a compound having the formula:

and
ii) deprotecting the tosyl group to form the compound of formula 1070 or a pharmaceutically acceptable salt thereof.

2. A method preparing a compound of formula 1070:

or a pharmaceutically acceptable salt thereof, comprising the steps of:
i) reacting a compound of formula

with a compound of formula

to form a compound having the formula:

and
ii) deprotecting the tosyl group to form the compound of formula 1070 or a pharmaceutically acceptable salt thereof.

Assignees

• Vertex Pharma

Inventors

• Charifson Paul S
• Clark Michael P
• Bandarage Upul K
• Bethiel Randy S
• Court John J
• Deng Hongbo
• Davies Ioana
• Duffy John P
• Farmer Luc J
• Gao Huai
• Gu Wenxin
• Jacobs Dylan H
• Kennedy Joseph M
• Ledeboer Mark W
• Ledford Brian
• Maltais Francois
• Perola Emanuele
• Wang Tiansheng
• Wannamaker M Woods
• Byrn Randal
• Zhou Yi
• Lin Chao
• Jiang Min
• Jones Steven
• Germann Ursula A
• Salituro Francesco G
• Kwong Ann Dak-Yee

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P37/04

  Immunostimulants · CPC title

• A61P31/16

  for influenza or rhinoviruses · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• C07D401/10 Primary

  linked by a carbon chain containing aromatic rings · CPC title