Method of treating presbyopia using dithiol compounds and their derivatives

Patent metadata

Field	Value
Publication number	US-10039743-B2
Application number	US-201615385164-A
Country	US
Kind code	B2
Filing date	Dec 20, 2016
Priority date	Aug 16, 2000
Publication date	Aug 7, 2018
Grant date	Aug 7, 2018

Abstract

Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

First claim

What is claimed is:

1. A method of treating presbyopia comprising administering to a subject a compound having the structure of Formula I or I-NC a pharmaceutically acceptable salt thereof:

wherein at least one of X and Y is sulfur, and the other is sulfur, selenium, or a sulfonic group;
R 19 is substituted or unsubstituted alkylene;
R 20 , R 21 , R 30 , and R 31 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
wherein R 30 and R 31 may optionally be joined together or together form a single bond;
Z is N or O; and m is 0 or 1, wherein if Z is 0, then m is 0, and if Z is N, then m is 1, and wherein the compound is not lipoic acid.

2. The method of claim 1 , wherein one of X and Y is sulfur, and the other is sulfur or selenium.

3. The method of claim 1 , wherein X and Y are both sulfur.

4. The method of claim 1 , wherein R 19 is unsubstituted alkylene.

5. The method of claim 4 , wherein R 19 is C 4 alkylene.

6. The method of claim 5 , wherein the compound has a structure of Formula III(R):

7. The method of claim 6 , wherein the compound is:

8. The method of claim 6 , wherein the compound has a structure of Formula IVB

wherein R 29 is the side chain of an alpha amino acid.

9. The method of claim 8 , wherein the compound is:

10. The method of claim 5 , wherein the compound has a structure of Formula VI(R):

11. The method of claim 10 , wherein R 21 is alkyl.

12. The method of claim 11 , wherein said compound has the structure

13. The method of claim 10 , wherein the compound is:

14. The method of claim 1 , wherein the compound is a tromethamine salt.

Assignees

• Encore Health Llc
• Novartis Ag

Inventors

• Garner William
• Garner Margaret
• Minno George
• Gooden David

Classifications

• C07D339/04

  having the hetero atoms in positions 1 and 2, e.g. lipoic acid · CPC title

• A61K31/497

  containing further heterocyclic rings · CPC title

• A61K31/095

  Sulfur, selenium, or tellurium compounds, e.g. thiols · CPC title

• A61K31/70

  Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047) · CPC title

• A61K31/385

  having two or more sulfur atoms in the same ring · CPC title