Methods for treating idiopathic pulmonary fibrosis

Patent metadata

Field	Value
Publication number	US-10039515-B2
Application number	US-201615263767-A
Country	US
Kind code	B2
Filing date	Sep 13, 2016
Priority date	May 3, 2012
Publication date	Aug 7, 2018
Grant date	Aug 7, 2018

Abstract

The present invention relates to methods and medicaments useful for treating idiopathic pulmonary fibrosis (IPF) by administering anti-CTGF antibodies. Methods for prognosing individuals with IPF are also provided.

First claim

What is claimed:

1. A method for treating idiopathic pulmonary fibrosis (IPF) in a subject in need thereof, the method comprising:
(a) taking a baseline measurement of a pulmonary radiographic parameter, wherein the pulmonary radiographic parameter is fibrosis;
(b) administering at least 15 mg/kg of an anti-CTGF antibody every three weeks, thereby stabilizing or producing at least a 2% reduction in fibrosis compared to the baseline measurement, wherein the anti-CTGF antibody is identical to the antibody produced by the cell line identified by ATCC Accession No. PTA-6006.

2. The method of claim 1 wherein administration of the anti-CTGF antibody also stabilizes or produces at least a 2% redaction, compared to a baseline measurement, in a pulmonary radiographic parameter selected from the group consisting of ground glass opacity and honeycomb formation.

3. The method of claim 1 , wherein the subject has a forced vital capacity percent (FVC %) predicted of greater than about 55% prior to treatment with the anti-CTGF antibody.

4. The method of claim 1 , wherein the subject has less than 50% parenchymal fibrosis prior to treatment with the anti-CTGF antibody.

5. The method of claim 1 , wherein the subject has less than 25% honeycombing within the whole lung prior to treatment the anti-CTGF antibody.

Assignees

• Fibrogen Inc

Inventors

• Porter Seth
• Stauffer John L

Classifications

• A61B6/50

  specially adapted for specific body parts; specially adapted for specific clinical applications · CPC title

• A61B6/5217 Primary

  extracting a diagnostic or physiological parameter from medical diagnostic data · CPC title

• A61K39/3955

  against proteinaceous materials, e.g. enzymes, hormones, lymphokines · CPC title

• A61B6/032

  Transmission computed tomography [CT] · CPC title

• C07K16/22 Primary

  against growth factors {; against growth regulators} · CPC title