Continuous calibration of a blood pressure measurement device

Patent metadata

Field	Value
Publication number	US-10039455-B2
Application number	US-201514714966-A
Country	US
Kind code	B2
Filing date	May 18, 2015
Priority date	May 19, 2014
Publication date	Aug 7, 2018
Grant date	Aug 7, 2018

Abstract

Systems, methods, and devices of the various embodiments enable continuous non-invasive monitoring of blood pressure with a minimum of interference. The various embodiments may provide a method for adaptation for the calibration for continuous measurements of blood pressure, wherein the measured quantity may be related to an arterial lumen or arterial cross sectional area comprising calibrating the conversion for incremental variations of arterial properties and absolute value adaptation by exploitation of the exponential decay during the diastole. In various embodiments, continuous calibration of a non-interfering blood pressure measurement device may be initiated based on a change in mean arterial pressure being greater than a threshold value, such as a pressure value associated with an actual measured distension of a patient's artery.

First claim

What is claimed is:

1. A method for calibration of a non-interfering blood pressure measurement device, comprising:
determining, by a processor, a pulse rate, a distension, a hydrostatic pressure, and an elevation at an artery of a patient at two observation times, wherein the pulse rate, the hydrostatic pressure, and the distension are determined based on a collection of outputs of an arterial measurement sensor of the non-interfering blood pressure measurement device and the elevation is determined based on one or more outputs of an elevation sensor of the non-interfering blood pressure measurement device;
determining, by the processor, a series of arterial pressures of the artery of the patient between the two observation times based on the collection of outputs of the arterial measurement sensor;
determining, by the processor, whether a change in both the distension and the elevation occurred between the two observation times;
determining, by the processor, whether a change in the pulse rate has occurred between the two observation times in response to determining that the change in both the distension and the elevation occurred between the two observation times;
determining, by the processor, an incremental variation between the two observation times in response to determining that no change in the pulse rate occurred between the two observation times, wherein the incremental variation is a change in hydrostatic pressure between the two observation times over the change in the distension between the two observation times;
determining, by the processor, an exponentially decaying function representing an exponential decay of the series of arterial pressures in a portion of a diastolic phase of a selected pulse that occurred between the two observation times;
determining, by the processor, a mean arterial pressure based at least in part on the exponentially decaying function and the incremental variation;
determining, by the processor, whether a change in mean arterial pressure determined as a difference between the determined mean arterial pressure and a previously determined mean arterial pressure is greater than a threshold pressure; and
calibrating, by the processor, the non-interfering blood pressure measurement device in response to determining that the change in mean arterial pressure is greater than the threshold pressure, wherein calibrating the non-interfering blood pressure measurement device comprises controlling, by the processor, the non-interfering blood pressure measurement device to enter a calibration mode.

2. The method of claim 1 , wherein determining, by the processor, the mean arterial pressure based at least in part on the exponentially decaying function and the incremental variation comprises:
determining, by the processor, a diastolic pressure based on the exponentially decaying function and the incremental variation;
determining, by the processor, a systolic blood pressure based at least in part on the determined diastolic pressure; and
determining, by the processor, the mean arterial pressure as two thirds of the determined diastolic pressure added to one third of the determined systolic blood pressure.

3. The method of claim 1 , wherein the arterial measurement sensor is one or more of a bioimpedance sensor, impedance plethysmography sensor, photoplethsmography sensor, ultrasound sensor, and surface pressure sensor.

4. The method of claim 1 , wherein calibrating the non-interfering blood pressure measurement device includes updating calibration values stored in a memory of the non-interfering blood pressure measurement device based on the change in mean arterial pressure and the change in distension.

5. The method of claim 1 , wherein determining, by the processor, whether the change in the pulse rate has occurred between the two observation times comprises localizing, by the processor, pulses that occurred between the two observation times by one or more of:
determining a zero crossing of a high-pass filter demodulated signal;
localizing maximum pulse gradients;
localizing based on a quantity related to the maximum and minimum of each pulse; and
wavelet filtering to extract shape and time information.

6. A device, comprising:
a processor in communication with a non-interfering blood pressure measurement device, wherein the processor is configured with processor executable instructions to perform operations to:
determine a pulse rate, a distension, a hydrostatic pressure, and an elevation at an artery of a patient at two observation times, wherein the pulse rate, the hydrostatic pressure, and the distension are determined based on a collection of outputs of an arterial measurement sensor of the non-interfering blood pressure measurement device and the elevation is determined based on one or more outputs of an elevation sensor of the non-interfering blood pressure measurement device;
determine a series of arterial pressures of the artery of the patient between the two observation times based on the collection of outputs of the arterial measurement sensor;
determine whether a change in both the distension and the elevation occurred between the two observation times;
determine whether a change in the pulse rate has occurred between the two observation times in response to determining that the change in both the distension and the elevation occurred between the two observation times;
determine an incremental variation between the two observation times in response to determining that no change in the pulse rate occurred between the two observation times, wherein the incremental variation is a change in hydrostatic pressure between the two observation times over the change in the distension between the two observation times;
determine an exponentially decaying function representing an exponential decay of the series of arterial pressures in a portion of a diastolic phase of a selected pulse that occurred between the two observation times;
determine a mean arterial pressure based at least in part on the exponentially decaying function and the incremental variation;
determine whether a change in mean arterial pressure determined as a difference between the determined mean arterial pressure and a previously determined mean arterial pressure is greater than a threshold pressure; and
calibrate the non-interfering blood pressure measurement device in response to determining that the change in mean arterial pressure is greater than the threshold pressure, wherein calibrating the non-interfering blood pressure measurement device comprises controlling the non-interfering blood pressure measurement device to enter a calibration mode.

7. The device of claim 6 , wherein the processor is configured with processor executable instructions to perform operations to determine the mean arterial pressure based at least in part on the exponentially decaying function and the incremental variation by:
determining a diastolic pressure based on the exponentially decaying function and the incremental variation;
determining a systolic blood pressure based at least in part on the determined diastolic pressure; and
determining the mean arterial pressure as two thirds of the determined diastolic pressure added to one third of the determined systolic blood pressure.

8. The device of claim 6 , wherein the arterial measurement sensor is one or more of a bioimpedance sensor, impedance plethysmography sensor, photoplethsmography sensor, ultrasound sensor, and surface pressure sensor.

9. The device of claim 6 , wherein the processor is further configured with processor executable instructions to perform operations to calibrate the non-interfering blood pressure measurement device by updating calibration values stored in

Assignees

• Qualcomm Inc

Inventors

• Lading Lars
• Baek David Boettcher

Classifications

• A61B5/725

  using specific filters therefor, e.g. Kalman or adaptive filters (specific diagnostics methods using using bioelectric or biomagnetic signals A61B5/316) · CPC title

• A61B5/02007

  Evaluating blood vessel condition, e.g. elasticity, compliance · CPC title

• A61B5/021

  Measuring pressure in heart or blood vessels · CPC title

• A61B5/02108 Primary

  from analysis of pulse wave characteristics · CPC title

• A61B5/1126

  using a particular sensing technique · CPC title