Probiotic compositions and methods

Patent metadata

Field	Value
Publication number	US-10039296-B2
Application number	US-201214127573-A
Country	US
Kind code	B2
Filing date	Jun 18, 2012
Priority date	Jun 20, 2011
Publication date	Aug 7, 2018
Grant date	Aug 7, 2018

Abstract

The present invention features compositions and methods for modulation of the mucosal immune system. The compositions include foods fermented by the probiotic organism, Lactobacillus paracasei CBA L74 (International Depository Accession Number LMG P-24778). Alternatively the compositions can include L. paracasei CBA L74 and a physiologically acceptable carrier. In some embodiments, the L. paracasei CBA L74 can be non-replicating. The compositions can be administered to a subject having or at risk for gastrointestinal disorders related to immaturity of the immune system, infection or disease.

First claim

What is claimed is:

1. A composition comprising a fermented food product, wherein the food product has been fermented by the probiotic bacterium, Lactobacillus paracasei CBA L74, International Depository Accession Number LMG P-24778, and any Lactobacillus paracasei CBA L74 cells present in the composition are dead or have been rendered incapable of cell division.

2. The composition of claim 1 , wherein the food product is a dairy product or a cereal product.

3. The composition of claim 2 , wherein the dairy product is milk, yoghurt, curd, cheese or an infant formula.

4. The composition of claim 2 , wherein the cereal product is rice, wheat, oats, barley, corn, rye, sorghum, millet, or triticale.

5. The composition of claim 1 , wherein the food product is dried.

6. The composition of claim 1 , wherein the food product comprises from about 1×10 2 cfu/g to about 10 12 cfu/g of probiotic bacteria per gram of dry weight.

7. A composition comprising the probiotic bacterium, Lactobacillus paracasei CBA L74, International Depository Accession Number LMG P-24778 and a physiologically acceptable carrier, wherein the Lactobacillus paracasei CBA L74 cells present in the composition are dead or have been rendered incapable of cell division.

8. The composition of claim 7 , wherein the physiologically acceptable carrier is a food product.

9. The composition of claim 8 , wherein the food product is a dairy product or a cereal product.

10. The composition of claim 7 , wherein the food product comprises from about 1×10 2 cfu/g to about 10 12 cfu/g of probiotic bacteria per gram of dry weight.

11. The composition of claim 7 , wherein the physiologically acceptable carrier is a pharmaceutically acceptable carrier.

12. The composition of claim 11 , wherein the probiotic bacterium is in a unit dosage form of about 1×10 2 cfu/g to about 1×10 12 cfu/g dry weight.

13. A composition comprising culture supernatant from probiotic bacterium, Lactobacillus paracasei CBA L74, International Depository Accession Number LMG P-24778, and a physiologically acceptable carrier, wherein any Lactobacillus paracasei CBA L74 cells present in the composition are dead or have been rendered incapable of cell division.

14. The composition of claim 13 , wherein the physiologically acceptable carrier is a food product.

Assignees

• Budelli Andrea
• Fasano Francesca Romana
• Terzano Miryam
• Bramati Lorenzo
• Heinz Co Brands H J Llc

Inventors

• Budelli Andrea
• Fasano Francesca Romana
• Terzano Miryam
• Bramati Lorenzo

Classifications

• A61P37/02

  Immunomodulators · CPC title

• A23L19/00

  Products from fruits or vegetables; Preparation or treatment thereof (marmalades, jams, jellies or the like A23L21/10; treating harvested fruit or vegetables in bulk A23N) · CPC title

• A61K2035/115

  Probiotics · CPC title

• A23C9/1234 Primary

  characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp. · CPC title

• A23L33/40

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title