Compositions and methods for modulating an immune response

Patent metadata

Field	Value
Publication number	US-10035858-B2
Application number	US-201415039524-A
Country	US
Kind code	B2
Filing date	Nov 25, 2014
Priority date	Nov 26, 2013
Publication date	Jul 31, 2018
Grant date	Jul 31, 2018

Abstract

Described herein are compositions for increasing IL-12 production comprising IgG or a fragment thereof or a variant thereof and uses of said compositions for treating cancer and infectious diseases. Also described herein are compositions for decreasing IL-12 production comprising an agent that inhibits signaling mediated by interaction between FcRn and IgG and uses of said compositions for treating autoimmune diseases. Further described herein are methods for assessing efficacy of treatment by monitoring levels of various cytokines in the subject.

First claim

We claim:

1. A method for determining the efficacy of treatment in a subject in need thereof comprising:
(a) administering to the subject a treatment comprising a composition comprising an anti-FcRn antibody that inhibits signaling mediated by interaction between FcRn and IgG;
(b) providing a sample from the subject, wherein the sample is blood, plasma or tissue;
(c) assaying the level of IL-12, in the sample; and
(d) determining that the treatment is efficacious if the level of IL-12, in the sample from the subject is lower relative to the level in a reference sample or determining that the treatment is not efficacious if the level of IL-12, in the sample from the subject is higher relative to the level in a reference sample,
wherein the subject has an autoimmune disease.

2. The method of claim 1 , wherein the antibody is selected from the group consisting of a monoclonal antibody or a fragment thereof, a polyclonal antibody or a fragment thereof, chimeric antibody, humanized antibody and single chain antibody.

Assignees

• Brigham & Womens Hospital Inc

Inventors

• Blumberg Richard S
• Baker Kristi
• Rath Timo

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P37/04

  Immunostimulants · CPC title

• A61P35/04

  specific for metastasis · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title