Sarm1 enzyme activity inhibitor and application thereof
US-2024368168-A1 · Nov 7, 2024 · US
US10035818B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10035818-B2 |
| Application number | US-201715472476-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 29, 2017 |
| Priority date | Nov 3, 2011 |
| Publication date | Jul 31, 2018 |
| Grant date | Jul 31, 2018 |
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The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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The invention claimed is: 1. A compound of the formula (IV) wherein n represents 0, 1, 2, or 3; and R 1 represents hydrogen, methyl, ethyl, n-propyl or isopropyl. 2. The compound of claim 1 wherein n represents 1 or 2; and R 1 is hydrogen or methyl. 3. The compound of claim 1 wherein the is a compound of formula (III)
Hormones (derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin C07K14/665, e.g. corticotropin C07K14/695) · CPC title
and aromatic or cycloaliphatic · CPC title
and aliphatic · CPC title
containing at least one abnormal peptide link · CPC title
the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol · CPC title
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