Implantable biomaterials having engineered functional surfaces

Patent metadata

Field	Value
Publication number	US-10034967-B2
Application number	US-201615219133-A
Country	US
Kind code	B2
Filing date	Jul 25, 2016
Priority date	Sep 26, 2002
Publication date	Jul 31, 2018
Grant date	Jul 31, 2018

Abstract

Implantable materials having defined patterns of affinity regions for binding endothelial cells and providing for directed endothelial cell migration across the surface of the material. The affinity regions include photochemically altered regions of a material surface and physical members patterned on the material surface that exhibit a greater affinity for endothelial cell binding and migration than the remaining regions of the material surface.

First claim

What is claimed is:

1. An implantable biomaterial having at least one surface thereof that comprises the biomaterial and a defined pattern of a plurality of functional features having a height above the at least one surface greater than 0μ, each of the plurality of functional features having a greater endothelial cell binding affinity greater than an endothelial cell binding affinity of the biomaterial.

2. The implantable biomaterial according to claim 1 , wherein each of the plurality of functional features further comprises a titanium oxide layer.

3. The implantable biomaterial according to claim 1 , wherein the biomaterial is made of a material that comprises a nickel-titanium alloy.

4. The implantable biomaterial according to claim 1 , wherein each of the plurality of functional features is made of a material that comprises carbon.

5. The implantable biomaterial according to claim 1 , wherein the functional features have a height between greater than 0μ to about 3.0μ.

6. The implantable biomaterial according to claim 1 , wherein each of the functional features comprises a focal adhesion point for affinity binding of endothelial cells.

7. The implantable biomaterial according to claim 1 , wherein each of the functional features has a width between about 10 μm to about 75 μm.

8. The implantable biomaterial according to claim 1 , further comprising a gap distance between adjacent functional features between about 10 μm to about 75 μm.

Assignees

• Advanced Bio Prosthetic Surfaces Ltd
• Vactronix Scientific Llc

Inventors

• Palmaz Julio C
• Sprague Eugene A

Classifications

• A61F2/02

  Prostheses implantable into the body · CPC title

• A61F2310/00616

  Coating made of titanium oxide or hydroxides · CPC title

• A61F2/00 Primary

  Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (dental prostheses A61C13/00; artificial kidneys A61M1/14; artificial hearts A61M60/00) · CPC title

• A61F2/0077

  Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence) · CPC title

• A61F2002/0086

  for preferentially controlling or promoting the growth of specific types of cells or tissues · CPC title