Synergistic nutritional compositions and uses thereof

Patent metadata

Field	Value
Publication number	US-10034937-B2
Application number	US-201514959107-A
Country	US
Kind code	B2
Filing date	Dec 4, 2015
Priority date	Dec 4, 2015
Publication date	Jul 31, 2018
Grant date	Jul 31, 2018

Abstract

Provided are nutritional compositions comprising a combination of a probiotic, dietary butyrate and/or a component for stimulating butyrate production in the human gut. Further disclosed are methods of accelerating tolerance to cow's milk allergy in a pediatric subject by providing said nutritional compositions to a target subject.

First claim

What is claimed is:

1. A nutritional composition, comprising per 100 Kcal:
(i) between about 6 g and about 22 g of a carbohydrate source;
(ii) between about 1 g and about 7 g of a protein source;
(iii) between about 1 g and about 10.3 g of a fat source;
(iv) between about 1×10 4 CFU to about 1.5×10 12 CFU of Lactobacillus rhamnosus GG; and
(v) between about 22 mg and 280 mg of dietary butyrate.

2. The nutritional composition of claim 1 , further comprising one or more long chain polyunsaturated fatty acids.

3. The nutritional composition of claim 1 , further comprising one or more prebiotics.

4. The nutritional composition of claim 1 , wherein the nutritional composition further comprises a component for stimulating endogenous butyrate production, wherein the component for stimulating endogenous butyrate production comprises polydextrose and galacto-oligosaccharides.

5. The nutritional composition of claim 1 , wherein the dietary butyrate comprises one or more of the following compounds selected from the group consisting of N-(1-carbamoyl-2-phenyl-ethyl) butyramide; N-(1-butyroyl-carbamoyl-2-phenyl-ethyl)butyramide; 5-benzyl-2-propyl-1H-imidazol-4(5H)-one; N-(1-oxo-3-phenyl-1-(piperidin-1-yl)propan-2-yl)butyramide; N-(1-oxo-3-phenyl-1-(pyrrolidin-1-yl)propan-2-yl)butyramide; N-(1-(methylcarbamoyl)-2-phenylethyl) butyramide; N-(1-(ethylcarbamoyl)-2-phenylethyl)butyramide; N-(1-(propylcarbamoyl)-2-phenylethyl)butyramide; N-(1-(butylcarbamoyl)-2-phenylethyl)butyramide; N-(1-(pentylcarbamoyl)-2-phenylethyl)butyramide; N-(1-carbamoyl-2-phenylethyl)-N-methyl butyramide; N-(1-carbamoyl-2-phenylethyl)-N-ethylbutyramide; N-(1-carbamoyl-2-phenylethyl)-N-propylbutyramide; and/or corresponding mixtures and corresponding salts of pharmaceutically acceptable bases or acids, pure diastereoisomeric forms and enantiomeric forms or mixtures thereof.

6. The nutritional composition of claim 2 , wherein the one or more long chain polyunsaturated fatty acids comprises docosahexaenoic acid, arachidonic acid, or combinations thereof.

7. The nutritional composition of claim 1 , further comprising a prebiotic comprising β-glucan.

Assignees

• Mead Johnson Nutrition Co

Inventors

• Lambers Teartse Tim
• Van Tol Eric A F

Classifications

• A61K31/702

  Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages · CPC title

• A23L1/296

  Human Necessities · mapped topic

• A23L1/308

  Human Necessities · mapped topic

• A61K2039/55594

  from bacteria · CPC title

• A61K2039/55511

  Organic adjuvants · CPC title