Composition for treating skin pigmentation

Patent metadata

Field	Value
Publication number	US-10034830-B2
Application number	US-201514660043-A
Country	US
Kind code	B2
Filing date	Mar 17, 2015
Priority date	Dec 22, 2011
Publication date	Jul 31, 2018
Grant date	Jul 31, 2018

Abstract

The invention relates to a topical composition containing a bilirubin-producing plant extract. In particular, the bilirubin-producing plant extract is obtained from the genus Stelitzia . When topically applied to skin, the composition is effective in accelerating the degradation of heme by-products such as bilirubin present in the skin.

First claim

What is claimed is:

1. A method for accelerating the degradation of bilirubin accumulated in the skin of a human suffering from a skin condition, comprising contacting the skin with a topical composition comprising:
(a) an extract from a bilirubin-producing plant;
(b) a preservative; and
(c) a dermatologically-acceptable vehicle;
wherein (a) is present in an amount from about 0.5% to about 20%; (b) is present in an amount from about 0.001% to about 3.0%; and (c) is present in an amount from about 75% to about 99.05%, to thereby alleviate the skin condition by said contacting.

2. The method according to claim 1 , wherein the extract contains components which cause accelerated degradation of bilirubin.

3. The method according to claim 1 , wherein the extract is derived from the whole bilirubin-producing plant, part of the plant, the seed of the plant, or a cell culture of the plant.

4. The method according to claim 1 , wherein the bilirubin-producing plant is from the genus Strelitzia or Phenakospermum.

5. The method according to claim 1 , wherein the bilirubin-producing plant is from the genus Strelitzia.

6. The method according to claim 1 , wherein the bilirubin-producing plant extract is from the species Strelitzia nicolai.

7. The method according to claim 1 , wherein the bilirubin-producing plant extract is taken from the seeds of the bilirubin-producing plant species Strelitzia nicolai.

8. The method according to claim 1 , wherein the bilirubin-producing plant extract is taken from the arils of the seeds of the bilirubin-producing plant Strelitzia nicolai.

9. The method according to claim 1 , wherein the bilirubin-producing plant extract is present in an amount from about 0.5% to about 5%.

10. The method according to claim 1 , wherein the topical composition diminishes dark pigments of the human skin when applied topically.

11. The method according to claim 10 , wherein the dark pigments of the human skin is due to accumulation of blood and blood degradation by-products.

12. The method according to claim 10 , wherein the dark pigment is a result of the skin condition selected from the group consisting of: (a) bruising; (b) dark circles under the eyes; (c) spider veins; and (d) port wine stains.

13. The method of claim 1 , wherein the bilirubin-producing plant extract is included in a delivery system selected from the group consisting of:
(a) liposome;
(b) niasome;
(c) polymerisome; and
(d) dendrimerosome.

14. The method according to claim 1 , wherein the condition is bruising.

15. The method according to claim 1 , wherein the condition is dark circles under the eyes.

16. The method according to claim 1 , wherein the condition is spider veins.

17. The method according to claim 1 , wherein the condition is port wine stains.

18. The method according to claim 1 , wherein the bilirubin-producing plant extract is present in an amount from about 0.5% to about 1%.

19. The method according to claim 1 , wherein the bilirubin-producing plant extract is present in an amount from about 0.5% to about 10%.

20. The method according to claim 1 , wherein the bilirubin-producing plant extract is present in an amount from about 0.5% to about 15%.

Assignees

• Lonza Walkersville Inc
• Lonza Ag

Inventors

• Gruber James V
• Ludwig Philip L

Classifications

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• A61P17/16

  Emollients or protectives, e.g. against radiation · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• Y10T436/145555

  Hetero-N · CPC title

• A61Q19/02

  for chemically bleaching or whitening the skin · CPC title