Method and system for obtaining low dose tomosynthesis and material decomposition images

Patent metadata

Field	Value
Publication number	US-10032294-B2
Application number	US-201514978460-A
Country	US
Kind code	B2
Filing date	Dec 22, 2015
Priority date	Dec 24, 2014
Publication date	Jul 24, 2018
Grant date	Jul 24, 2018

Abstract

Method and system for obtaining tomosynthesis and material decomposition images of an object of interest using a system comprising an x-ray source facing a detector. The method comprises generating a 2D material decomposition image of an object of interest from at least two sets of acquisitions. Each set is performed at a different energy spectrum and comprises at least one projection image or a plurality of projection images acquired at different x-ray source angulation positions, and the 2D material decomposition image can be generated for a predetermined orientation selected from one of said different x-ray source angulation positions or from a virtual orientation. At least one of the plurality of 3D volume portion images and/or the 2D contrast enhanced material decomposition image are displayed for review by a health care professional.

First claim

What is claimed is:

1. A Method for obtaining tomosynthesis and material decomposition images of an object of interest using a system comprising an x-ray source facing a detector, the method comprising:
acquiring a plurality of 2D projection images of the object of interest in a plurality of orientations based on different x-ray source angulation positions using x-ray radiation having a first energy spectrum, when the system is operating in a first mode;
generating from the plurality of 2D projection images tomosynthesis data comprising a plurality of 3D volume portion images of the object of interest;
acquiring a 2D image of the object of interest in a predetermined orientation using X-ray radiation having a second energy spectrum, when the system is operating in a second mode;
generating a synthetic 2D image from the tomosynthesis data of the first energy spectrum in a predetermined orientation; and
generating a 2D material decomposition image of the object of interest from the two sets of acquisitions, each performed at a different energy spectrum, by combining the synthetic 2D image of the first energy spectrum and the 2D image acquired at the second energy spectrum, wherein the material decomposition image can be generated for a predetermined orientation selected from one of said different x-ray source angulation positions or from a virtual orientation.

2. The method according to claim 1 , further comprising:
displaying at least one of the plurality of 3D volume portion images and/or the 2D material decomposition image.

3. The method according claim 1 , further comprising providing a breast of a patient as an object, wherein a material is a contrast agent introduced in the patient's breast before the system is operating in the first and second mode.

4. The method according to claim 1 , wherein the x-ray source angulation positions are the same, the method further comprising:
recombining the sets of projection images to obtain a series of projection images representing the material; and
reconstructing the resulting recombined projections to generate a 3D volume of the material, which is reprojected to generate a synthetic 2D material decomposition image.

5. The method according to claim 1 , wherein each of the sets of projection images are reconstructed to obtain 3D volumes, the method further comprising; recombining said 3D volumes to obtain a 3D volume representing the material and said 3D volume is then reprojected to generate a synthetic 2D material decomposition image.

6. The method according to claim 1 , further comprising performing the tomosynthesis acquisition at a first energy spectrum comprising a low energy (LE), which is lower than the high energy (HE) level of the second energy spectrum.

7. The method according to claim 1 , wherein the total dose after image acquisitions in the first and second mode is about equal to the dose of a dual energy 2D contrast enhanced spectral mammography (CESM).

8. The method according to claim 2 , wherein displaying further comprises switching between the display of 3D volume portions and the synthetic 2D image and the 2D material decomposition image.

9. The method according to claim 8 , wherein a user actuated switching between the display of 3D volume portions or synthetic 2D image and the 2D material decomposition image is provided using a progressive fading functionality.

10. The method according to claim 1 , wherein the generation of a synthetic 2D image provides a navigation map linking each pixel of the synthetic 2D image to the height of a 3D volume portion.

11. The method according to claim 10 , wherein clicking on a pixel of the 2D material decomposition image or the synthetic 2D image allows displaying the 3D volume portion of height provided by the navigation map in that pixel.

12. The method according to claim 10 , wherein the navigation map is merged with the 2D material decomposition image preferably by using color information.

13. The method according to claim 1 , further comprising displaying the synthetic 2D image, wherein object characteristics such as vascular information based on the combined 2D material decomposition image are added on demand as highlighted and/or colored region to the synthetic 2D image.

14. The method according to claim 1 , further comprising displaying a volume portion, wherein object characteristics such as vascular information based on the combined 2D material decomposition image are added on demand as highlighted and/or colored region to the volume portion.

15. A non-transitory computer readable medium storing program instructions, which, when executed by a computer cause the computer to perform the method according to claim 1 .

16. A system for obtaining tomosynthesis and material decomposition images of an object of interest, the system comprising:
an x-ray source and an x-ray detector to acquire a plurality of 2D projection images of the object of interest in a plurality of orientations based on different x-ray source angulation positions using x-ray radiation having a first energy spectrum in a first mode and to acquire a 2D image of the object of interest using x-ray radiation having a second energy spectrum in a predetermined orientation in a second mode; and
a processor to generate a plurality of 3D volume portions of the object of interest from the plurality of 2D projection images and to generate a 2D material decomposition image by combining a synthetic 2D image of the first energy spectrum and the 2D image acquired at the second energy spectrum, wherein the 2D material decomposition image is generated for a predetermined orientation selected from one of the different x-ray source angulation positions or from a virtual orientation.

17. The system according to claim 16 , further comprising:
a display unit for displaying at least one 3D volume portion of the object of interest and/or the 2D material decomposition image.

18. The system according to claim 16 , wherein the object of interest is a patient's breast comprising as material an introduced contrast agent.

Assignees

• Gen Electric

Inventors

• Bernard Sylvain
• Iordache Razvan Gabriel
• Muller Serge Louis Wilfrid
• Palma Giovanni John Jacques
• Carton Ann-Katherine
• Milioni De Carvalho Pablo

Classifications

• G06T12/20 Primary

  Inverse problem, i.e. transformations from projection space into object space · CPC title

• G06T2211/436

  Limited angle · CPC title

• G06T2211/408

  Dual energy · CPC title

• A61B6/482

  involving multiple energy imaging · CPC title

• A61B6/025 Primary

  Tomosynthesis · CPC title