Method of making an optically-activated system
US-9545371-B2 · Jan 17, 2017 · US
Method of stabilizing riboflavin
US10030022B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10030022-B2 |
| Application number | US-201514664418-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 20, 2015 |
| Priority date | Mar 20, 2015 |
| Publication date | Jul 24, 2018 |
| Grant date | Jul 24, 2018 |
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Abstract
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A method of stabilizing riboflavin by affixing the riboflavin to at least one substrate for the riboflavin by covalent bonding, hydrogen bonding, Van der Waals forces, or a combination thereof, to form an optically-activated complex, is provided. When activated by absorption of light in the ultraviolet (UV) to visible region of the electromagnetic spectrum the riboflavin in the complex re-emits light of longer wavelength in the blue-green-yellow region of the electromagnetic spectrum.
First claim
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What is claimed is: 1. A method for stabilizing riboflavin against degradation upon exposure to UV light by (a) mixing a silicone polyamide substrate with a solution of riboflavin, and (b) evaporating the liquid to form an optically-activated complex in the form of a gel that will absorb light in the wavelength range of 260 to 460 nm and emit light in the wavelength range of 470 to 650 nm. 2. The method of claim 1 , wherein the silicone polyamide substrate is a particulate, and the method comprises (a) mixing the at least one particulate with a solution of the riboflavin for a time sufficient for the solution of riboflavin to be absorbed into pores of the at least one particulate, and (b) heating the at least one particulate substrate having the riboflavin solution absorbed in the pores thereof under vacuum to remove nonabsorbed liquid so as to entrap the riboflavin in the pores. 3. The method of claim 1 , wherein the at least one silicone polyamide substrate further comprises at least one particulate substrate, and the method further comprises (c) mixing the gel thus-produced with the at least one particulate substrate for a time sufficient to permit the gel to be absorbed into pores of the at least one particulate substrate, and thereafter (d) removing nonabsorbed liquid. 4. The method of claim 2 , further comprising (c) mixing the at least one silicone polyamide particulate substrate having riboflavin entrapped in the pores thereof with a further solution of riboflavin for a time sufficient to permit the further solution of riboflavin to be absorbed into the pores of the at least one particulate substrate, and thereafter (d) removing nonabsorbed liquid; wherein optionally, (c) and (d) are repeated at least one time. 5. The method of claim 1 , wherein the riboflavin is present in the gel in amounts in the range of from about 0.001% to about 2%, by total weight of the gel. 6. The method of claim 5 , wherein the at least one silicone polyamide substrate for the riboflavin is present in the gel in amounts in the range of from about 0.05% to about 25%, by total weight of the gel. 7. A stable form of riboflavin produced by the method of claim 1 . 8. A stable form of riboflavin produced by the method of claim 2 . 9. A stable form of riboflavin produced by the method of claim 3 . 10. A stable form of riboflavin produced by the method of claim 4 .
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Classifications
Vitamin B group · CPC title
Drugs for dermatological disorders · CPC title
Porous; Hollow · CPC title
Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof · CPC title
Luminescent, Fluorescent; Optical brighteners; Photosensitizers · CPC title
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- What does patent US10030022B2 cover?
- A method of stabilizing riboflavin by affixing the riboflavin to at least one substrate for the riboflavin by covalent bonding, hydrogen bonding, Van der Waals forces, or a combination thereof, to form an optically-activated complex, is provided. When activated by absorption of light in the ultraviolet (UV) to visible region of the electromagnetic spectrum the riboflavin in the complex re-emits…
- Who is the assignee on this patent?
- Elc Man Llc
- What technology area does this patent fall under?
- Primary CPC classification C07D475/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 24 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).