Container for accommodating at least one of at least one biologically active fluid and at least one preparatory fluid, and a method therefor

Patent metadata

Field	Value
Publication number	US-10029425-B2
Application number	US-201514680180-A
Country	US
Kind code	B2
Filing date	Apr 7, 2015
Priority date	Apr 7, 2015
Publication date	Jul 24, 2018
Grant date	Jul 24, 2018

Abstract

A sterilizable container for accommodating at least one of at least one biologically active fluid and at least one preparatory fluid has an area within the container configured to accommodate at least one sterilizable three-dimensional printer assembly. The sterilizable three-dimensional printer assembly includes at least one printing platform; at least one printer head for dispensing structural material onto the at least one printing platform to form thereon a three-dimensional structure; and a moving mechanism for providing a relative displacement between the at least one printer head and the at least one printing platform. The area is configured so that the fluid can reach the printer assembly.

First claim

What is claimed is:

1. A sterilizable container for exposing a sterile three-dimensional structure to at least one of at least one biologically active fluid and at least one preparatory fluid, comprising:
a sterilizable printer assembly housing that occupies a first area within the container;
a sterilizable three-dimensional printer assembly disposed in the printer assembly housing and including:
at least one printing platform,
at least one printer head for dispensing structural material onto the at least one printing platform in order to form thereon a three-dimensional structure, and
a moving mechanism for providing a relative displacement between the at least one printer head and the at least one printing platform;
a second area in the container configured to contain at least one of the biologically active fluid and the preparatory fluid in a sterile state and isolated from the first area of the container; and
a selectively openable passage between the first and second areas of the container, such that the fluid can reach the three-dimensional structure formed by the printer assembly in the first area of the container.

2. The container of claim 1 , wherein the moving mechanism comprises at least one curved arm that is supported by a supporting surface arranged adjacent to the at least one printing platform, wherein at least one printer head is attached to the curved arm.

3. The container of claim 2 , wherein the curved arm is movable between a retracted position and an extended position with respect to the supporting surface.

4. The container of claim 3 , wherein the curved arm extends through a through hole in the supporting surface.

5. The container of claim 2 , wherein the at least one printer head is at least one of movable along the curved arm and pivotable with respect to the curved arm.

6. The container of claim 1 , wherein the printer head has at least one dispenser for dispensing the structural material onto the at least one printing platform, wherein the dispenser is fixed or movable with respect to the printer head.

7. The container of claim 2 , wherein the supporting surface is movable or stationary.

8. The container of claim 2 , further comprising a driving assembly arranged at an underside of the printer assembly for actuating at least one of the at least one curved arm and the at least one printing platform and the supporting surface, wherein the underside of the printer assembly is sealed with respect to an upper side of the printer assembly where the three-dimensional structure is formed by the printer assembly.

9. The container of claim 8 , further comprising a feed assembly arranged at the underside of the printer assembly and connected to the at least one printer head via at least one conduit extending through the at least one curved arm for feeding the at least one printer head with the structural material for forming the three-dimensional structure in the first area of the container.

10. The container of claim 1 , wherein the printer assembly housing comprises at least one of at least one controlled fluid inlet port and at least one controlled fluid outlet port for allowing a fluid exchange between the printer assembly housing and the second area of the container.

11. The container of claim 1 , wherein the printer assembly housing is openable.

12. The container of claim 1 , wherein the container is one of a bioreactor and a mixing container.

Assignees

• Sartorius Stedim Biotech Gmbh

Inventors

• Maggiore Frank

Classifications

• B29C64/379

  Handling of additively manufactured objects, e.g. using robots · CPC title

• B29C64/35

  Cleaning · CPC title

• B29C64/25

  Housings, e.g. machine housings · CPC title

• A61L2103/23

  Containers other than laboratory or medical, e.g. bottles or mail · CPC title

• C12M33/00

  Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus (chemical or physical laboratory apparatus in general B01L, devices for taking cell samples A61B10/0045, withdrawing or distributing predetermined quantities of fluid B01L99/00) · CPC title