Hollow-fiber membrane blood purification device

Patent metadata

Field	Value
Publication number	US-10029216-B2
Application number	US-201415104072-A
Country	US
Kind code	B2
Filing date	Dec 16, 2014
Priority date	Dec 16, 2013
Publication date	Jul 24, 2018
Grant date	Jul 24, 2018

Abstract

Disclosed is a hollow-fiber membrane blood purification device having an improved antioxidant performance, good water permeation performance and blood compatibility performance, and economic rationality. The present invention provides a hollow-fiber membrane blood purification device including hollow-fiber membranes filled in a vessel, in which the hollow-fiber membranes contain a hydrophobic polymer, a hydrophilic polymer and a fat-soluble vitamin, when a hollow-fiber membrane bundle is divided into five sections in a lengthwise direction and divided sections positioned in endmost portions are defined as body end portions, an amount of the fat-soluble vitamin present in at least one of the body end portions is the largest among amounts of the fat-soluble vitamin present respectively in all the divided sections, and an amount of the fat-soluble vitamin per m2 of a hollow-fiber membrane inner surface of the at least one body end portion is 20 mg/m2 or more and 300 mg/m2 or less.

First claim

The invention claimed is:

1. A hollow-fiber membrane blood purification device comprising hollow-fiber membranes filled in a vessel,
wherein the hollow-fiber membranes contain a hydrophobic polymer, a hydrophilic polymer and a fat-soluble vitamin,
when a hollow-fiber membrane bundle is divided into five equally sized sections in a lengthwise direction and divided sections positioned in endmost portions are defined as body end portions, an amount of the fat-soluble vitamin present in at least one of the body end portions is the largest amount of the fat-soluble vitamin present in any of the individual divided sections, and an amount of the fat-soluble vitamin per m 2 of a hollow-fiber membrane inner surface of the at least one body end portion is 20 mg/m 2 or more and 300 mg/m 2 or less.

2. The hollow-fiber membrane blood purification device according to claim 1 , wherein when an amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the body end portion where the amount of the fat-soluble vitamin is the largest is defined as A (mg/m 2 ) and an amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in a divided section where the amount of the fat-soluble vitamin is the smallest among the other divided sections is defined as B (mg/m2), a ratio (A/B) between the amounts A and B is 1.1 or more and 10 or less.

3. The hollow-fiber membrane blood purification device according to claim 2 , wherein the ratio (A/B) between the amounts A and B is 1.3 or more and 10 or less.

4. The hollow-fiber membrane blood purification device according to claim 3 , wherein when within an inner circle having a ½ radius of the hollow-fiber membrane bundle is defined as a center portion and a portion not included in the center portion is defined as an outside portion, an amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the center portion is larger than an amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the outside portion.

5. The hollow-fiber membrane blood purification device according to claim 4 , wherein when the amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the center portion is defined as C (mg/m 2 ) and the amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the outside portion is defined as D (mg/m 2 ), a ratio (C/D) between the amounts C and D is 1.1 or more and 50 or less.

6. The hollow-fiber membrane blood purification device according to claim 5 , wherein the hydrophilic polymer is polyvinylpyrrolidone.

7. The hollow-fiber membrane blood purification device according to claim 2 , wherein when within an inner circle having a ½ radius of the hollow-fiber membrane bundle is defined as a center portion and a portion not included in the center portion is defined as an outside portion, an amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the center portion is larger than an amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the outside portion.

8. The hollow-fiber membrane blood purification device according to claim 7 , wherein when the amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the center portion is defined as C (mg/m 2 ) and the amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the outside portion is defined as D (mg/m 2 ), a ratio (C/D) between the amounts C and D is 1.1 or more and 50 or less.

9. The hollow-fiber membrane blood purification device according to claim 8 , wherein the hydrophilic polymer is polyvinylpyrrolidone.

10. The hollow-fiber membrane blood purification device according to claim 1 , wherein when within an inner circle having a ½ radius of the hollow-fiber membrane bundle is defined as a center portion and a portion not included in the center portion is defined as an outside portion, an amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the center portion is larger than an amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the outside portion.

11. The hollow-fiber membrane blood purification device according to claim 10 , wherein when the amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the center portion is defined as C (mg/m 2 ) and the amount of the fat-soluble vitamin per m 2 of the hollow-fiber membrane inner surface present in the outside portion is defined as D (mg/m 2 ), a ratio (C/D) between the amounts C and D is 1.1 or more and 50 or less.

12. The hollow-fiber membrane blood purification device according to claim 11 , wherein the hydrophilic polymer is polyvinylpyrrolidone.

13. The hollow-fiber membrane blood purification device according to claim 1 , wherein the hydrophobic polymer has a solubility parameter δ (cal/cm 3 ) 1/2 of 13.0 or less.

14. The hollow-fiber membrane blood purification device according to claim 13 , wherein the hydrophilic polymer is polyvinylpyrrolidone.

15. The hollow-fiber membrane blood purification device according to claim 1 , wherein the hydrophobic polymer is any one selected from the group consisting of polysulfones, polyethersulfones and cellulose acetates.

16. The hollow-fiber membrane blood purification device according to claim 15 , wherein the hydrophilic polymer is polyvinylpyrrolidone.

17. The hollow-fiber membrane blood purification device according to claim 1 , wherein the hydrophilic polymer is polyvinylpyrrolidone.

Assignees

• Asahi Kasei Medical Co Ltd

Inventors

• Hori Ryoko
• Hata Yosuke
• KAWAKAMI Junya

Classifications

• A61P7/08

  Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title

• C08L2205/025

  containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure · CPC title

• B01D69/08

  Hollow fibre membranes (manufacture of hollow fibres D01D5/24, D01F1/08) · CPC title

• C08L2203/12

  used for fibers · CPC title

• B01D69/144 Primary

  containing embedded or bound biomolecules · CPC title