Systems and methods for interior energy-activation from an exterior source

Patent metadata

Field	Value
Publication number	US-10029117-B2
Application number	US-201514729864-A
Country	US
Kind code	B2
Filing date	Jun 3, 2015
Priority date	Apr 8, 2007
Publication date	Jul 24, 2018
Grant date	Jul 24, 2018

Abstract

A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

First claim

The invention claimed is:

1. A method for curing an adhesive, comprising:
disposing in contact with an interior surface of a plastic or rubber object an adhesive composition comprising 1) an uncured radiation-curable medium, 2) an energy modulation agent selected from the group consisting of telluride semiconductors, selenide semiconductors, oxide semiconductors, Y 2 O 3 ; ZnSe; Mn, Er ZnSe; Mn; Mn, Yb ZnSe; Mn, Y 2 O 3 :Tb 3+ ; Y 2 O 3 :Tb 3+ , Er 3+ ; CdSe, Y 2 O 3 :Eu 3+ , Y 2 O 3 :Eu 3+ ; BaFBr:Tb 3+ ; and YF 3 :Tb 3+ , and 3) a photo-activated photoinitiator;
applying energy from at least one of x-rays, gamma rays, or an electron beam through the plastic or rubber structure into the composition, wherein the energy interacts with the energy modulation agent and internally generates light inside the uncured radiation-curable medium at the interior surface of the plastic or rubber object and
activating the photoinitiator in the radiation-curable medium with the internally generated light and thereby curing or sterilizing the radiation-curable medium.

2. The method of claim 1 , wherein the object comprises a medical device.

3. The method of claim 1 , wherein disposing comprises disposing at least one of a telluride, a selenide, and an oxide semiconductor as the energy modulation agent.

4. The method of claim 1 , wherein the disposing comprises disposing at least one of Y 2 O 3 ; ZnSe; Mn, Er ZnSe; Mn; Mn, Yb ZnSe; Mn, Y 2 O 3 :Tb 3+ ; Y 2 O 3 :Tb 3+ , Er 3+ ; CdSe, Y 2 O 3 :Eu 3+ , Y 2 O 3 :Eu 3+ ; BaFBr:Tb 3+ ; and YF 3 :Tb 3+ as the energy modulation agent.

5. The method of claim 1 , wherein the activating comprises: activating the photoinitiator with 200-280 nm wavelength ultraviolet light.

6. The method of claim 1 , wherein the activating comprises: activating the photoinitiator with 280-320 nm wavelength ultraviolet light.

7. The method of claim 1 , wherein the activating comprises: activating the photoinitiator with 320-400 nm wavelength ultraviolet light.

8. The method of claim 1 , wherein the activating comprises: activating the photoinitiator with 350-400 nm wavelength ultraviolet light.

9. The method of claim 1 , wherein the photoinitiator comprises at least one of at least one of benzoin, substituted benzoins, Michler's ketone, dialkoxyacetophenones, diethoxyacetophenone, benzophenone, substituted benzophenones, acetophenone, substituted acetophenones, xanthone, substituted xanthones, diethoxyxanthone, chloro-thio-xanthone, azo-bisisobutyronitrile, N-methyl diethanolaminebenzophenone, camphoquinone, peroxyester initiators, non-fluorene-carboxylic acid peroxyesters and mixtures thereof.

10. The method of claim 1 , wherein the photoinitiator comprises a weight percentage of the uncured radiation-curable medium ranging from 0.1% to 10%.

11. The method of claim 1 , wherein the photoinitiator comprises a weight percentage of the uncured radiation-curable medium ranging from 2 to 6%.

12. The method of claim 1 , wherein the uncured radiation-curable medium includes a moisture cure catalyst.

13. A method for curing an adhesive, comprising:
disposing in contact with an interior surface of a plastic or rubber object an adhesive composition comprising 1) an uncured radiation-curable medium comprising a UV-curable silicone, 2) an energy modulation agent selected from the group consisting of telluride semiconductors, selenide semiconductors, oxide semiconductors, Y 2 O 3 ; ZnSe; Mn, Er ZnSe; Mn; Mn, Yb ZnSe; Mn, Y 2 O 3 :Tb 3+ ; Y 2 O 3 :Tb 3+ , Er 3+ ; CdSe, Y 2 O 3 :Eu 3+ , Y 2 O 3 :Eu 3+ ; BaFBr:Tb 3+ ; and YF 3 :Tb 3+ , and 3) a photo-activated photoinitiator;
applying energy from at least one of x-rays, gamma rays, or an electron beam through the plastic or rubber structure into the composition, wherein the energy interacts with the energy modulation agent and internally generates light inside the uncured radiation-curable medium at the interior surface of the plastic or rubber object and
activating the photoinitiator in the radiation-curable medium with the internally generated light and thereby curing or sterilizing the radiation-curable medium.

14. The method of claim 13 , wherein the object comprises a medical device.

15. The method of claim 13 , wherein disposing comprises disposing at least one of a telluride, a selenide, and an oxide semiconductor as the energy modulation agent.

16. The method of claim 13 , wherein the disposing comprises disposing at least one of Y 2 O 3 ; ZnSe; Mn, Er ZnSe; Mn; Mn, Yb ZnSe; Mn, Y 2 O 3 :Tb 3+ ; Y 2 O 3 :Tb 3+ , Er 3+ ; CdSe, Y 2 O 3 :Eu 3+ , Y 2 O 3 :Eu 3+ ; BaFBr:Tb 3+ ; and YF 3 :Tb 3+ as the energy modulation agent.

17. The method of claim 13 , wherein the activating comprises: activating the photoinitiator with 200-280 nm wavelength ultraviolet light.

18. The method of claim 13 , wherein the activating comprises: activating the photoinitiator with 280-320 nm wavelength ultraviolet light.

19. The method of claim 13 , wherein the activating comprises: activating the photoinitiator with 320-400 nm wavelength ultraviolet light.

20. The method of claim 13 , wherein the activating comprises: activating the photoinitiator with 350-400 nm wavelength ultraviolet light.

21. The method of claim 13 , wherein the UV-curable silicone comprises an organopolysiloxane.

22. The method of claim 13 , wherein the UV-curable silicone includes a methacrylate group.

23. The method of claim 13 , wherein the UV-curable silicone includes an acryloxy group.

24. The method of claim 13 , wherein the UV-curable silicone includes at least one of carboxylate, maleate, and cinnamate.

25. The method of claim 13 , wherein the UV-curable silicone includes at least one of trimethylsilyl, dimethylsilyl, phenyldimethylsilyl, vinyldimethylsilyl, trifluoropropyldimethylsilyl, (4-vinylphenyl)dimethylsilyl, (vinylbenzyl)dimethylsilyl, and (vinylphenethyl)dimethylsilyl.

26. The method of claim 13 , wherein the photoinitiator comprises at least one of at least one of benzoin, substituted benzoins, Michler's ketone, dialkoxyacetophenones, diethoxyacetophenone, benzophenone, substituted benzophenones, acetophenone, substituted acetophenones, xanthone, substituted xanthones, diethoxyxanthone, chloro-thio-xanthone, azo-bisisobutyronitrile, N-methyl diethanolaminebenzophenone, camphoquinone, peroxyester initiators, non-fluorene-carboxylic acid peroxyesters and mixtures thereof.

27. The method of claim 13 , wherein the photoinitiator comprises a weight percentage of the uncured radiation-curable medium ranging from 0.1% to 10%.

28. The method of claim 13 , wherein the photoinitiator comprises a weight percentage of the uncured radiation-curable medium ranging from 2 to 6%.

29. The method of claim 13 , wherein the uncured radiation-curable medium includes a moisture cure catalyst.

30. A method for curing an adhesive, comprising:
disposing in contact with an interior surface of a plastic or rubber object an adhesive composition comprising 1) an uncured radiation-curable medium, 2) an energy modulation agent selected from the group consisting of telluride semiconductors, selenide semiconductors, oxide semiconductors, Y 2 O 3 ; ZnSe; Mn, Er ZnSe; Mn; Mn, Yb ZnSe; Mn, Y 2 O 3 :Tb 3+ ; Y 2 O 3 :Tb 3+ , Er 3+ ; CdSe, Y 2 O 3 :Eu 3+ , Y 2 O 3 :Eu 3+ ; BaFBr:Tb 3+ ; and YF 3 :Tb 3+ , and 3) a photo-activated photoinitiator; wherein

Assignees

• Immunolight Llc
• Immunolight Llc

Inventors

• Bourke Jr Frederic A

Classifications

• A61P7/08

  Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P31/18

  for HIV · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61L2/088

  using photocatalysts or photosensitisers · CPC title