Surfactant-free, water-free formable composition and breakable foams and their uses

Patent metadata

Field	Value
Publication number	US-10029013-B2
Application number	US-201013499709-A
Country	US
Kind code	B2
Filing date	Oct 1, 2010
Priority date	Oct 2, 2009
Publication date	Jul 24, 2018
Grant date	Jul 24, 2018

Abstract

A substantially surface active agent-free and foam adjuvant-free composition which includes a hydrophobic solvent, a wax and a propellant. A substantially surface active agent-free and foam adjuvant-free composition, further comprising, a tetracycline antibiotic, or one or More other active agents. A method of treatment, using a substantially surface active agent-free and substantially foam adjuvant-free composition.

First claim

The invention claimed is:

1. A waterless foamable composition free of surfactant and polymeric agent comprising:
a carrier comprising:
a) about 50% to about 90% by weight of the carrier of a liquid oil and about 10% to about 50% by weight of the carrier of a paraffin wax that has a melting point between about 47° C. and about 64° C., wherein the total weight of the liquid oil and paraffin wax together is between about 85% and about 100% by weight of the carrier; or
b) about 40% by weight of the carrier of a liquid oil and about 60% by weight of the carrier of a paraffin wax that has a melting point between about 42° C. and about 44° C.; and
a liquefied or compressed gas propellant; and
a tetracycline antibiotic;
wherein the ratio of the carrier to the propellant is from about 100:4 to about 100:25;
wherein the composition comprises less than 5% foam adjuvant; and
wherein upon dispensing the foamable composition from a container, the composition forms a breakable foam that is stable, yet breaks easily upon application of shear force.

2. The composition of claim 1 , further comprising at least one active agent.

3. The composition of claim 2 , wherein the active agent is selected from the group consisting of an active herbal extract, an acaricide, an age spot and keratose removing agent, an allergen, an alpha hydroxyl acid, an analgesic agent, an antiacne agent, an antiallergic agent, an antiaging agent, an antibacterial agent, an antibiotic, an antiburn agent, an anticancer agent, an antidandruff agent, an antidepressant, an antidermatitis agent, an antiedemic agent, an antifungal agent, an antihistamine, an antihelminth agent, an antihyperkeratolyte agent, an anti-infective agent, an antiinflammatory agent, an antiirritant, an antilipemic agent, an antimicrobial agent, an antimycotic agent, an antioxidant, an antiparasitic agent, an antiproliferative agent, an antipruritic agent, an antipsoriatic agent, an antirosacea agent, an antiseborrheic agent, an antiseptic agent, an antiswelling agent, an antiviral agent, an anti-wart agent, an anti-wrinkle agent, an antiyeast agent, an astringent, a beta-hydroxy acid, benzoyl peroxide, a topical cardiovascular agent, a chemotherapeutic agent, a corticosteroid, an immunogenic substance, a dicarboxylic acid, a disinfectant, a fungicide, a hair growth regulator, a haptene, a hormone, a hydroxy acid, an immunosuppressant, an immunoregulating agent, an immunomodulator, an insecticide, an insect repellent, a keratolytic agent, a lactam, a local anesthetic agent, a lubricating agent, a masking agent, a metals, a metal oxide, a mitocide, a neuropeptide, a non-steroidal anti-inflammatory agent, an oxidizing agent, a pediculicide, a peptide, a protein, a photodynamic therapy agent, a radical scavenger, a refatting agent, a retinoid, a sanative, a scabicide, a self tanning agent, a skin protective agent, a skin whitening agent, a steroid, a steroid hormone, a vasoconstrictor, a vasodilator, a vitamin, a vitamin A, a vitamin A derivative, a vitamin B, a vitamin B derivative, a vitamin C, a vitamin C derivative, a vitamin D, a vitamin D derivative, a vitamin D analog, a vitamin F, a vitamin F derivative, a vitamin K, a vitamin K derivative, a wound healing agent and a wart remover, an androgen, an anti-hyperkeratosis agent, an estrogen, an immunestimulant, a pesticide, a progesterone, a sedative, a vaso active agent, and a mixture of any two or more thereof.

4. The composition of claim 1 , wherein the tetracycline antibiotic is a minocycline or a doxycycline.

5. The composition of claim 3 , wherein the active agent is a retinoid.

6. The composition of claim 1 , wherein the carrier comprises about 1% or less than 1% by weight of a foam adjuvant.

7. The composition of claim 1 , wherein the composition is foam adjuvant free.

8. The composition of claim 1 , wherein the carrier comprises about 5% or less than 5% by weight of the carrier of polyols.

9. The composition of claim 1 , wherein the paraffin wax is selected from the group consisting of a paraffin wax 58-62° C., a paraffin wax 51-53° C., and a paraffin wax 42-44° C., and a mixture thereof.

10. The composition of claim 1 , wherein the composition is free of short chain alcohols.

11. The composition of claim 1 , wherein the composition is a single phase.

12. The composition of claim 1 , further comprising a solid or semi-solid oil.

13. The composition of claim 1 , wherein the composition is short chain alcohol free and polyol free.

14. The composition of claim 1 , wherein the propellant is a hydrocarbon propellant or a hydrofluorocarbon or another environmentally acceptable propellant.

15. The composition of claim 1 , wherein the composition further comprises a wax selected from a hydrogenated castor oil, beeswax, and a mixture thereof.

16. The composition of claim 2 , wherein the active agent is suitable for treating a disorder selected form the group consisting of abscess, acne, acne conglobata, acne fulminans, acne vulgaris, acne scars, acute febrile neutrophilic dermatosis, acute lymphangitis, allergic contact dermatitis, alopecia, athlete's foot, atopic dermatitis, bacterial skin infections, baldness, basal cell carcinoma, blisters, bromhidrosis, bullous pemphigoid, burn, calluses candidiasis, carbuncles, cellulitis, chemical burns, chicken pox, cholesteatoma, cholinergic urticaria, chronic effects of sunlight, cold sores, cold urticaria, comedones, corns, creeping eruption, cutaneous abscess, cutaneous larva migrans, cutaneous myiasis, dark spots, delusional parasitosis, Dercum disease, dermatitis, dermatitis herpetiformis, dermatological pain, dermatological inflammation, dermographism, dermatophytoses, drug eruptions and reactions, dyshidrotic eczema, ectodermal dysplasia, eczema, ecthyma, epidermoid cyst, epidermal necrolysis, erysipelas, erysipelas, erythrasma, exfoliative dermatitis, erythema multiforme, erythema nodosum, folliculitis, fungal nail infections, fungal skin infections, furuncles, gangrene, genital herpes, granuloma annulare, head lice, hidradenitis suppurativa, hives, folliculitis, hirsutism, hyperhidrosis, hypohidrosis, ichthyosis, impetigo, inflammatory acne, ingrown nails, intertrigo, irritant contact dermatitis, ischemic necrosis, itching, jock itch, Kaposi's sarcoma, keratosis pilaris, lichen simplex chronicus, lichen planus, lichen sclerosus, lymphadenitis, lymphadenitis, lymphangitis, malignant melanoma, mastocytosis, measles, melanoma, miliaria, moles, molluscum contagiosum, MRSA, necrotizing subcutaneous infection, necrotizing fasciitis, necrotizing myositis, nodular papulopustular acne, non-inflammatory acne, nummular dermatitis, oral herpes, panniculitis, parapsoriasis paronychia, parasitic skin infections, pemphigus, photo-allergy, photo-damage, photo-irritation, photosensitivity, papules, pediculosis, perioral dermatitis, pimples, pityriasis rosea, pityriasis Lichenoides, pityriasis rosea, pityriasis rubra pilaris, poison ivy, poison oak post-operative or post-surgical skin conditions, pressure ulcers, pressure urticaria, pruritis, pseudofolliculitis barbae, psoriasis, PUPPP, purpura, pustules, pyogenic granuloma, rash, ringworm, rosacea, roseola, rubella, scabies, scalded skin syndrome, scarring, scleroderma, sebaceous cyst, seborrheic dermatitis, seborrheic keratosis, shingles, skin aging, skin cancer, skin neoplasia, skin neoplasms, skin rash, skin ulcers, squamous cell carcinoma, staphylococcal scalded skin syndrome, stasis dermatitis, Stevens-Johnson syndrome, sunburn, sun spots, thermal burns, tinea corporis, tinea cruris, tinea pedis, tinea versicolor, toxic epidermal necrolysis, trauma

Assignees

• Tamarkin Dov
• Gazal Elana
• Papiashvili Irakliy
• Hazot Yohan
• Schuz David
• Keynan Rita
• Foamix Pharmaceuticals Ltd

Inventors

• Tamarkin Dov
• Gazal Elana
• Papiashvili Irakliy
• Hazot Yohan
• Schuz David
• Keynan Rita

Classifications

• A61P39/06

  Free radical scavengers or antioxidants · CPC title

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• A61P37/04

  Immunostimulants · CPC title

• A61P37/02

  Immunomodulators · CPC title