Sixteen-membered macrolide compound and applications thereof

Patent metadata

Field	Value
Publication number	US-10028507-B2
Application number	US-201515125001-A
Country	US
Kind code	B2
Filing date	Mar 10, 2015
Priority date	Mar 10, 2014
Publication date	Jul 24, 2018
Grant date	Jul 24, 2018

Abstract

A sixteen-membered macrolide compound and use thereof, the compound structure being represented in formula (I), wherein R is CH 3 or C 2 H 5 . The present compound has a wide range of application in the preparation of chemicals for preventing and controlling insect pests and mites of agriculture and forestry.

First claim

The invention claimed is:

1. A mixture of tenvermectin A and tenvermectin B, the structural formula of tenvermectin is:

wherein, R is CH3 or C2H5, when R is CH3, the compound is tenvermectin A, and when R is C2H5, the compound is tenvermectin B; the mass ratio between tenvermectin A and tenvermectin B is 1:9.

2. A method for controlling insect pests or mites of agriculture and forestry including applying the mixture of tenvermectin A and tenvermectin B according to claim 1 or chemicals containing the mixture of tenvermectin A and tenvermectin B according to claim 1 to any plant suffering from insect pests or mites of agriculture and forestry.

3. The method for controlling insect pests or mites of agriculture and forestry according to claim 2 , wherein the agriculture and forestry insect pest is one or more selected from Lepidoptera Plutellidae, Lepidoptera Noctuidae, Lepidoptera Lasiocampidae, Lepidoptera borer, Coleoptera Elateridae , and Tylenchida Aphelenchoidea , and/or the agriculture and forestry mite is leaf mites.

4. The method for controlling insect pests or mites of agriculture and forestry according to claim 3 , wherein the insect pest of Lepidoptera plutellidae is Plutella xylostella , and/or the insect pest of Lepidoptera noctuidae is one or more selected from Spodoptera exigua, Prodenia litura, Mythimna separate Walker, Helicoverpa armigera Hubner and Agrotis ipsilon , and/or the insect pest of lepidoptera lasiocampidae is pine moth, and/or the insect pest of Lepidoptera borer is rice stem borer, and/or the insect pest of Coleoptera Elateridae is wireworm, and/or the insect pest of Tylenchida Aphelenchoidea is Bursaphelenchus xylophilus , and/or the agriculture and forestry mite is one or more selected from Tetranychus cinnabarinus, Tetranychus urticae Koch and citrus spider mite.

5. The method for controlling insect pests or mites of agriculture and forestry according to claim 2 , wherein the dosage form of the chemicals is water dispersible granules, emulsifiable concentrate, aqueous suspension, oil suspension, microemulsion or tablets.

6. The method for controlling insect pests or mites of agriculture and forestry according to claim 5 , wherein the water dispersible granules or tablets comprise the mixture according to claim 1 , a filler or a solvent, and a surfactant in a weight ratio of 0.5-90%:10-95%: 3-20%; and preferably, 0.5-87%:10-95%:3-20%.

7. The method for controlling insect pests or mites of agriculture and forestry according to claim 5 , wherein the emulsifiable concentrate comprises the said mixture, a solvent and a surfactant in a weight ratio of 0.5-90%:5-85%:2-15%.

8. The method for controlling insect pests or mites of agriculture and forestry according to claim 5 , wherein the aqueous suspension or the oil suspension comprises the said mixture, water or a solvent, and a surfactant in a weight ratio of 0.5-90%:5-80%:5-20%; and preferably, 0.5-90%:10-80%:5-20%.

9. The method for controlling insect pests or mites of agriculture and forestry according to claim 5 , wherein the microemulsion comprises the said mixture, water or a solvent and a surfactant in a weight ratio of 0.5-50%:40-95%:4-15%.

10. The method for controlling insect pests or mites of agriculture and forestry according to claim 5 , wherein the water dispersible granules comprise the said mixture, a filler and a surfactant in a weight ratio of 0.5-60%:30-98%:1-25%; and preferably, 0.5-60%:30-90%:4-20%; the tablets comprise the said mixture, a filler and a surfactant in a weight ratio of 0.5-90%:8-85%:2-20%; and preferably, 0.5-90%:15-85%:2-20%.

11. The method for controlling insect pests or mites of agriculture and forestry according to claim 6 , wherein the filler is one of white carbon black, bentonite and diatomaceous earth, or the mixture of any two or more.

12. The method for controlling insect pests or mites of agriculture and forestry according to claim 6 , wherein the solvent is one of methanol, ethanol, isopropanol, n-butanol and rosin oil, or the mixture of any two or more.

13. The method for controlling insect pests or mites of agriculture and forestry according to claim 6 , wherein the surfactant is one or more selected from nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyoxyethylene stearyl ether, polyoxyethylene lauryl ether, polyoxyethylene rosin ester, sorbitan fatty acid ester, alkylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether-formaldehyde condensate, calcium dodecylbenzene sulfonate, dodecyl trimethyl ammonium chloride and betaine.

14. The method for controlling insect pests or mites of agriculture and forestry according to claim 2 , wherein the application mode is spraying or broadcasting.

15. The method for controlling insect pests or mites of agriculture and forestry according to claim 7 , wherein the solvent is one of methanol, ethanol, isopropanol, n-butanol and rosin oil, or the mixture of any two or more; and/or the surfactant is one or more selected from nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyoxyethylene stearyl ether, polyoxyethylene lauryl ether, polyoxyethylene rosin ester, sorbitan fatty acid ester, alkylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether-formaldehyde condensate, calcium dodecylbenzene sulfonate, dodecyl trimethyl ammonium chloride and betaine.

16. The method for controlling insect pests or mites of agriculture and forestry according to claim 8 , wherein the solvent is one of methanol, ethanol, isopropanol, n-butanol and rosin oil, or the mixture of any two or more; and/or the surfactant is one or more selected from nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyoxyethylene stearyl ether, polyoxyethylene lauryl ether, polyoxyethylene rosin ester, sorbitan fatty acid ester, alkylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether-formaldehyde condensate, calcium dodecylbenzene sulfonate, dodecyl trimethyl ammonium chloride and betaine.

17. The method for controlling insect pests or mites of agriculture and forestry according to claim 9 , wherein the solvent is one of methanol, ethanol, isopropanol, n-butanol and rosin oil, or the mixture of any two or more; and/or the surfactant is one or more selected from nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyoxyethylene stearyl ether, polyoxyethylene lauryl ether, polyoxyethylene rosin ester, sorbitan fatty acid ester, alkylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether-formaldehyde condensate, calcium dodecylbenzene sulfonate, dodecyl trimethyl ammonium chloride and betaine.

18. The method for controlling insect pests or mites of agriculture and forestry according to claim 10 , wherein the filler is one of white carbon black, bentonite and diatomaceous earth, or the mixture of any two or more; and/or the surfactant is one or more selected from nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyoxyethylene stearyl ether, polyoxyethylene lauryl ether, polyoxyethylene rosin ester, sorbitan fatty acid ester, alkylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether-formaldehyde con

Assignees

• Zhejiang Hisun Pharm Co Ltd
• Zhejiang Hisun Chemical Co Ltd

Inventors

• Huang Jun
• Wang Jidong
• Zhang Hui
• Wang Lingping
• Li Na
• Li Meihong
• Bai Hua
• Jin Minqi

Classifications

• A01N43/90 Primary

  having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system · CPC title

• C07H17/08

  Hetero rings containing eight or more ring members, e.g. erythromycins · CPC title

• A01N43/24

  with two or more hetero atoms · CPC title