Microfluidics with wirelessly powered electronic circuits

Patent metadata

Field	Value
Publication number	US-10024819-B2
Application number	US-201113880973-A
Country	US
Kind code	B2
Filing date	Oct 21, 2011
Priority date	Oct 21, 2010
Publication date	Jul 17, 2018
Grant date	Jul 17, 2018

Abstract

Techniques, devices and systems are described for incorporating a printed circuit with a microfluidic device and wirelessly powering the microfluidic device. In one aspect, a microfluidic device includes a substrate with a fluidic channel to provide a path for a fluid with particles. The fluidic channel includes fluid inlet and outlet. A pair of electrodes near the inlet and the outlet guides the particles toward a center of the fluidic channel using negative-dielectrophoresis (DEP) effect in response to an alternating current (AC) frequency voltage received at the pairs of electrodes. Additional pairs of electrodes are disposed along a border of the fluidic channel between the pairs of electrodes near the inlet and the outlet of the fluidic channel to isolate a subpopulation of the particles using positive and negative DEP effects in response to AC voltages of different frequencies received at different ones of the additional pairs of electrodes.

First claim

What is claimed is:

1. A microfluidic device, comprising:
a fluidic channel in a substrate with an inlet to receive a fluid with particles suspended in the fluid and one or more sheath flow inlets to receive sheath flow;
at least one pair of DC electrodes positioned near the inlet, the at least one pair of DC electrodes configured to electrophoretically separate suspended particles when supplied with a direct current (DC) voltage;
pairs of AC electrodes arranged along the fluidic channel, the pairs of AC electrodes configured to sort the separated particles using one or more of a positive dielectrophoresis (DEP) effect and a negative dielectrophoresis effect when each of the different pairs of AC electrodes are supplied with alternating current (AC) voltages at different frequencies, wherein each pair of AC electrodes includes a circularly shaped electrode and a straight electrode, and wherein the particles experiencing the positive DEP effect are attracted to an edge of the circularly shaped electrodes, and particles experiencing the negative DEP effect are diverted toward paths between the circularly shaped electrodes;
a printed integrated circuit on the substrate configured to produce the AC voltages at the different frequencies, wherein the printed integrated circuit includes one or more active electronic devices; and
an inductor on the substrate configured to couple power from a wireless radio frequency (RF) signal emanating from an external transmitter to the integrated circuit.

2. The microfluidic device of claim 1 , wherein the fluidic channel has a free-flow design to allow the fluid to spread out transverse to a flow direction.

3. The microfluidic device of claim 1 , wherein the at least one pair of DC electrodes are configured to separate the particles into groups according to one or more of a charge, a shape, or a mass based on an electrophoretic (EP) effect.

4. The microfluidic device of claim 1 , wherein each of the pairs of AC electrodes is configured to receive an AC voltage that is different in frequency from at least another of the pairs of AC electrodes.

5. The microfluidic device of claim 1 , wherein each of the pairs of AC electrodes has an asymmetric geometry.

6. The microfluidic device of claim 1 , wherein a gradient of an electric field is zero.

7. The microfluidic device of claim 1 , wherein the substrate includes one or more of a glass, a polymer, or a plastic.

8. The microfluidic device of claim 1 , wherein the inductor comprises loops to inductively couple the power from the wireless RF signal to the integrated circuit.

9. The microfluidic device of claim 1 , wherein the inductor includes silver, and wherein the inductor is a printed inductor printed on the substrate using silver gravure ink.

10. A method of sorting particles, comprising:
receiving a sample fluid with suspended particles at an inlet of a fluidic channel in a substrate and receiving a sheath flow at one or more sheath flow inlets;
electrophoretically separating the suspended particles by supplying at least one pair of direct current (DC) electrodes positioned near the inlet with a DC voltage;
sorting the separated particles via pairs of alternating current (AC) electrodes arranged along the fluidic channel, the sorting using one or more of a positive dielectrophoresis (DEP) effect and a negative dielectrophoresis effect, wherein each of the pairs of AC electrodes are supplied with AC voltages at different frequencies, wherein each pair of AC electrodes includes a circularly shaped electrode and a straight electrode, and wherein the particles experiencing the positive DEP effect are attracted to an edge of the circularly shaped electrodes, and particles experiencing the negative DEP effect are diverted toward paths between the circularly shaped electrodes;
producing the AC voltages at the different frequencies via a printed integrated circuit on the substrate, wherein the printed integrated circuit includes one or more active electronic devices; and
receiving a coupled power at an inductor on the substrate from a wireless radio frequency (RF) signal emanating from an external transmitter to the integrated circuit.

11. The method of sorting particles of claim 10 , wherein the fluidic channel has a free-flow design to allow the fluid sample to spread out transverse to a flow direction.

12. The method of sorting particles of claim 10 , wherein the at least one pair of DC electrodes are configured to separate the particles into groups according to one or more of a charge, a shape, or a mass based on an electrophoretic (EP) effect.

13. The method of sorting particles of claim 10 , wherein each of the pairs of AC of electrodes is configured to receive an AC voltage that is different in frequency from at least another of the pairs of AC electrodes.

14. The method of sorting particles of claim 10 , wherein each of the pairs of AC electrodes has an asymmetric geometry.

15. The method of sorting particles of claim 10 , wherein a gradient of an electric field is zero.

16. The method of sorting particles of claim 10 , wherein the substrate includes one or more of a glass, a polymer, or a plastic.

17. The method of sorting particles of claim 10 , wherein the inductor comprises loops to inductively couple the coupled power from the wireless RF signal to the integrated circuit.

18. The method of sorting particles of claim 10 , wherein the inductor includes silver, and wherein the inductor is a printed inductor printed on the substrate using silver gravure ink.

Assignees

• Lo Yu Hwa
• Qiao Wen
• Cho Gyoujin
• Kang Hwiwon
• Univ California
• Industry Academic Cooperation Foundation Of Sunchon National Univ

Inventors

• Lo Yu-Hwa
• Qiao Wen
• Cho Gyoujin
• Kang Hwiwon

Classifications

• B01L2200/0668

  Trapping microscopic beads · CPC title

• B01L2200/12

  Specific details about manufacturing devices · CPC title

• G01N27/44704 Primary

  Details; Accessories · CPC title

• B01L2200/10

  Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept · CPC title

• B01L2300/0887

  Laminated structure · CPC title