19-nor neuroactive steroids and methods of use thereof

Patent metadata

Field	Value
Publication number	US-10023606-B2
Application number	US-201615273125-A
Country	US
Kind code	B2
Filing date	Sep 22, 2016
Priority date	Apr 17, 2013
Publication date	Jul 17, 2018
Grant date	Jul 17, 2018

Abstract

Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I):

and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.

First claim

What is claimed is:

1. A compound of Formula (I):

or a pharmaceutically acceptable salt thereof;
wherein:
represents a single or double bond;
R 1 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl;
R 2 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl, or OR A2 , wherein R A2 is hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl;
R 3a is hydrogen or —OR A3 , wherein R A3 is hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl, and R 3b is hydrogen; or R 3a and R 3b are joined to form an oxo (═O) group;
each instance of R 4a and R 4b is independently hydrogen, substituted or unsubstituted alkyl, alkoxy, halogen, or —OR A4 , wherein R A4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl, provided if the between C5 and C6 is a single bond, then the hydrogen at C5 is in the alpha or beta configuration; and provided if the between C5 and C6 is a double bond, R 4b is absent;
A is one of the following formulae:

each instance of R 5 is, independently, halogen, —NO 2 , —CN, —OR GA , —N(R GA ) 2 , —C(═O)R GA , —C(═O)OR GA , —OC(═O)R GA , —OC(═O)OR GA , —C(═O)N(R GA ) 2 , —N(R GA )C(═O)R GA , —OC(═O)N(R GA ) 2 , —N(R GA )C(═O)OR GA , —S(═O) 2 R GA , —S(═O) 2 OR GA , —OS(═O) 2 R GA , —S(═O) 2 N(R GA ) 2 , or —N(R GA )S(═O) 2 R GA ; substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-4 carbocylyl, substituted or unsubstituted 3- to 4-membered heterocylyl, or optionally two R GA are taken with the intervening atoms to form a substituted or unsubstituted 3- to 4-membered carbocyclic or heterocyclic ring;
each instance of R AN is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, —C(═O)R GA , —C(═O)OR GA , —C(═O)N(R GA ) 2 , —S(═O) 2 R GA , —S(═O) 2 OR GA , —S(═O) 2 N(R GA ) 2 , —S(O)R GA , e.g., —S(═O)R GA , —S(═O)OR GA , —S(═O)N(R GA ) 2 , or a nitrogen protecting group;
each instance of R GA is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocylyl, substituted or unsubstituted 3- to 6-membered heterocylyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, or two R GA groups are taken with the intervening atoms to form a substituted or unsubstituted carbocyclic or heterocyclic ring;
p is 1 or 2; and
e is 0, 1, 2, 3, 4, or 5;
provided that when A is (A-3) or (A-5), e is 1, 2, 3, 4, or 5.

2. A compound of claim 1 , wherein the compound is of Formula (II):

or a pharmaceutically acceptable salt thereof.

3. A compound of Formula (IV):

or a pharmaceutically acceptable salt thereof.

4. A compound of claim 1 , wherein the compound is of Formula (V):

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 4 , wherein R AN is substituted or unsubstituted hydrogen, substituted or unsubstituted C 1-6 alkyl, —C(═O)R GA , —C(═O)OR GA , —C(═O)N(R GA ) 2 , or —S(═O) 2 R GA .

6. A compound of claim 1 , wherein the compound is of Formula (VI):

or a pharmaceutically acceptable salt thereof.

7. The compound of claim 6 , wherein the compound is of Formula (VI-a):

8. The compound of claim 1 , wherein e is 1.

9. The compound of claim 1 , wherein R 5 is substituted or unsubstituted C 1-6 alkyl.

10. The compound of claim 1 , wherein R 5 is —CH 3 .

11. The compound of claim 1 , wherein R 5 is OR GA wherein R GA is hydrogen or substituted or unsubstituted C 1-6 alkyl.

12. The compound of claim 1 , wherein R 5 is OH.

13. The compound of claim 1 , wherein R 5 is —S(═O) 2 R GA wherein R GA is substituted or unsubstituted C 1-6 alkyl.

14. The compound of claim 1 , wherein R 5 is —S(═O) 2 CH 3 .

15. The compound of claim 1 , wherein R 5 is —C(═O) R GA wherein R GA is substituted or unsubstituted C 1-6 alkyl.

16. The compound of claim 1 , wherein R 5 is —C(═O)CH 3 .

17. The compound of claim 1 , wherein R 5 is —C(═O)N(R GA ) 2 wherein R GA is hydrogen or substituted or unsubstituted C 1-6 alkyl.

18. The compound of claim 1 , wherein R 5 is —C(═O)NHCH 3 .

19. The compound of claim 1 , wherein between C5 and C6 is a double bond and R 4b is absent.

20. The compound of claim 1 , wherein between C5 and C6 is a single bond.

21. The compound of claim 1 , wherein the compound is selected from the group consisting of:

22. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

23. A method for positively modulating a GABA receptor in a sub

Assignees

• Sage Therapeutics Inc

Inventors

• Martinez Botella Gabriel
• Harrison Boyd L
• Robichaud Albert Jean
• Salituro Francesco G
• Beresis Richard Thomas

Classifications

• A61P25/30

  for treating abuse or dependence · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/18

  Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia · CPC title

• A61P25/08

  Antiepileptics; Anticonvulsants · CPC title

• C07J43/003 Primary

  not condensed · CPC title