Near-infrared dye-conjugated hyaluronic acid derivative and contrast agent for optical imaging including them
US-2015374856-A1 · Dec 31, 2015 · US
Medical tissue-marker and manufacturing method for the same
US10022459B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10022459-B2 |
| Application number | US-201214126034-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 31, 2012 |
| Priority date | Jun 13, 2011 |
| Publication date | Jul 17, 2018 |
| Grant date | Jul 17, 2018 |
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Abstract
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A medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also a manufacturing method for the medical tissue-marker. The medical tissue-marker includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by use of an emulsifier.
First claim
Opening claim text (preview).
What is claimed is: 1. A medical tissue-marker comprising: a plurality of capsules formed and aggregated by an emulsifier, each capsule containing a hydrophilic solvent, a vesicle and an emulsion, wherein the vesicle is formed by combining a phospholipid and a near-infrared fluorescent dye, the emulsion is formed by combining the phospholipid and an X-ray contrast medium, the X-ray contrast medium is also provided outside of the capsules, the phospholipid is phosphatidylcholine and the X-ray contrast medium is a member selected from the group consisting of iodobenzene and derivatives thereof and barium salt and mixtures thereof. 2. The medical tissue-marker according to claim 1 , wherein the hydrophilic solvent includes water and an edible thickener.
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Classifications
liposome, i.e. bilayered vesicular structure · CPC title
General or multifunctional contrast agents, e.g. chelated agents · CPC title
Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery · CPC title
Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles · CPC title
Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol · CPC title
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- What does patent US10022459B2 cover?
- A medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also a manufacturing method for the medical tissue-marker. The medical tissue-marker includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluor…
- Who is the assignee on this patent?
- Hayashi Hideki, Hatayama Hirosuke, Fujinami Masanori, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification A61K49/0034. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).