Hemostatic preparation containing an extract of golden moss

Patent metadata

Field	Value
Publication number	US-10022410-B2
Application number	US-97558910-A
Country	US
Kind code	B2
Filing date	Dec 22, 2010
Priority date	Dec 22, 2010
Publication date	Jul 17, 2018
Grant date	Jul 17, 2018

Abstract

The present invention relates generally to agents and devices for promoting hemostasis and, more particularly, to an extract of a plant-based “Traditional Chinese Medicinal” product and devices incorporating such agents for the delivery thereof to bleeding wounds.

First claim

We claim:

1. A topical hemostatic preparation comprising effective amounts of:
a solvent extract of the rhizomes of Golden Moss,
a gelatin in powder form,
and a saline solution.

2. The hemostatic preparation of claim 1 , wherein the gelatin comprises an absorbable hemostatic powder matrix.

3. The hemostatic preparation of claim 2 , wherein the gelatin and extract are substantially homogenously mixed in combination with a saline solution as a liquid phase.

4. The hemostatic preparation of claim 3 , wherein the extract of the rhizomes of Golden Moss is an ethanol extract.

5. The hemostatic preparation of claim 4 , comprising from about 1% to about 2.5% of the ethanol extract of Golden Moss.

6. The hemostatic preparation of claim 3 , wherein the extract of Golden Moss is a water extract.

7. The hemostatic preparation of claim 6 , comprising from about 0.25% to about 2.5% of the water extract of Golden Moss.

8. The hemostatic preparation of claim 1 further comprising effective amounts of one or more additives or compounds selected from the group consisting of antimicrobial agents, surfactants, antioxidants, humectants, wetting agents, lubricants, thickeners, diluents, irradiation stabilizers, radical scavengers, plasticizers, and stabilizers.

9. The hemostatic preparation of claim 1 further comprising an extrusion enhancing amount of glycerol.

10. The hemostatic preparation of claim 9 wherein the glycerol is present at an amount from about 1% to about 20% by weight, based on the weight of the liquid phase.

11. The hemostatic preparation of claim 1 , wherein the solvent extract is a lyophilized concentrate.

12. The hemostatic preparation of claim 1 , wherein the solvent extract is a dried concentrate substantially free of solvent.

13. The hemostatic preparation of claim 12 , wherein the gelatin has a concentration of between 4 to 10%.

14. The hemostatic preparation of claim 13 , wherein the gelatin has a centration of at least 6%.

Assignees

• Wang yi lan
• Ming Xintian
• Ethicon Inc

Inventors

• Wang Yi-Lan
• Ming Xintian

Classifications

• A61P7/04

  Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L2400/04

  Materials for stopping bleeding · CPC title

• A61K36/41 Primary

  Crassulaceae (Stonecrop family) · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title