Sheet tissue products

Patent metadata

Field	Value
Publication number	US-10022214-B2
Application number	US-201615351935-A
Country	US
Kind code	B2
Filing date	Nov 15, 2016
Priority date	Dec 20, 2011
Publication date	Jul 17, 2018
Grant date	Jul 17, 2018

Abstract

The present disclosure provides a tissue product comprising a tissue sheet. The sheet can be formed from a plurality of tissue matrix fragments.

First claim

What is claimed is:

1. A method for producing a tissue sheet product, comprising:
treating a tissue matrix to produce a plurality of elongated tissue matrix fragments having a length between about 5 μm and 300 μm, at least a portion of the plurality of elongated tissue matrix fragments including frayed ends;
joining a portion of the plurality of elongated tissue matrix fragments to one another to form a first sheet of material;
joining a portion of the plurality of elongated tissue matrix fragments to one another to form at least one additional sheet of material; and
contacting the at least one additional sheet of material with the first sheet of material to make a multilayer material.

2. The method of claim 1 , further comprising drying each of the first sheet of material and the at least one additional sheet of material.

3. The method of claim 2 , wherein the first sheet of material and the at least one additional sheet of material are dried separately.

4. The method of claim 1 , wherein the first sheet of material or the at least one additional sheet of material are formed into a sheet using a process comprising compressing groups of the plurality of elongated tissue matrix fragments.

5. The method of claim 1 , wherein treating the tissue matrix to produce the plurality of elongated tissue matrix fragments includes milling the tissue matrix.

6. The method of 1 , wherein the plurality of tissue matrix fragments are strands of tissue matrix.

7. The method of claim 1 , wherein the tissue matrix is acellular tissue matrix.

8. The method of claim 1 , further comprising rolling the plurality of elongated tissue fragments to align at least some of the fragments along an axis of at least one sheet of material.

9. The method of claim 8 , wherein the first sheet of material and the at least one additional sheet of material are contacted such that the plurality of elongated tissue matrix fragments of the first sheet of material are oriented in a different direction relative to the plurality of elongated tissue matrix fragments of the at least one additional sheet of material.

10. The method of claim 1 , comprising contacting the first sheet of material with at least two additional sheets of material to form a multilayer material.

11. The method of claim 1 , comprising:
contacting the first sheet of material with at least three additional sheets of material to form a multilayer material.

12. A method for producing a tissue sheet product, comprising:
processing a tissue matrix to produce a plurality of elongated tissue matrix fragments having a length between about 5 μm and 300 μm, at least a portion of the plurality of elongated tissue matrix fragments including frayed ends;
joining a portion of the plurality of elongated tissue matrix fragments to one another to form a first sheet of material; and
joining a portion of the plurality of elongated tissue matrix fragments to one another on a surface of the first sheet of material to form at least one additional sheet of material stacked on the first sheet of material to form a multilayer material.

13. The method of claim 12 , further comprising drying each of the first sheet of material and the at least one additional sheet of material.

14. The method of claim 12 , wherein the first sheet of material or the at least one additional sheet of material are formed into a sheet using a process comprising compressing groups of the plurality of elongated tissue matrix fragments.

15. The method of claim 12 , wherein treating the tissue matrix to produce the plurality of elongated tissue matrix fragments includes milling the tissue matrix.

16. The method of 12 , wherein the plurality of tissue matrix fragments are strands of tissue matrix.

17. The method of claim 12 , wherein the tissue matrix is acellular tissue matrix.

18. The method of claim 12 , further comprising rolling the plurality of elongated tissue fragments to align at least some of the fragments along an axis of at least one sheet of material.

19. The method of claim 18 , wherein the first sheet of material and the at least one additional sheet of material are formed such that the plurality of elongated tissue matrix fragments of the first sheet of material are oriented in a different direction relative to the plurality of elongated tissue matrix fragments of the at least one additional sheet of material.

20. A method for producing a tissue sheet product, comprising:
treating a tissue matrix to produce a plurality of elongated tissue matrix fragments having a length between about 5 μm and 300 μm, at least a portion of the plurality of elongated tissue matrix fragments including frayed ends;
attaching a portion of the plurality of elongated tissue matrix fragments to one another to form a first sheet of material;
attaching a portion of the plurality of elongated tissue matrix fragments to one another to form at least one additional sheet of material; and
contacting the at least one additional sheet of material with the first sheet of material to make a multilayer material.

21. The method of claim 20 , further comprising drying each of the first sheet of material and the at least one additional sheet of material.

22. The method of claim 21 , wherein the first sheet of material and the at least one additional sheet of material are dried separately.

23. The method of claim 20 , wherein the first sheet of material or the at least one additional sheet of material are formed into a sheet using a process comprising compressing groups of the plurality of elongated tissue matrix fragments.

24. The method of claim 20 , wherein treating the tissue matrix to produce the plurality of elongated tissue matrix fragments includes milling the tissue matrix.

25. The method of 20 , wherein the plurality of tissue matrix fragments are strands of tissue matrix.

26. The method of claim 20 , wherein the tissue matrix is acellular tissue matrix.

27. The method of claim 20 , further comprising rolling the plurality of elongated tissue fragments to align at least some of the fragments along an axis of at least one sheet of material.

28. The method of claim 27 , wherein the first sheet of material and the at least one additional sheet of material are contacted such that the plurality of elongated tissue matrix fragments of the first sheet of material are oriented in a different direction relative to the plurality of elongated tissue matrix fragments of the at least one additional sheet of material.

29. The method of claim 20 , comprising contacting the first sheet of material with at least two additional sheets of material to form a multilayer material.

30. The method of claim 20 , comprising:
contacting the first sheet of material with at least three additional sheets of material to form a multilayer material.

Assignees

• Lifecell Corp

Inventors

• Hayzlett Mark

Classifications

• A61F2/28

  Bones · CPC title

• A61F2/08 Primary

  Muscles; Tendons; Ligaments · CPC title

• A61F2/105

  Skin implants, e.g. artificial skin · CPC title

• A61L27/362

  Skin, e.g. dermal papillae · CPC title

• A61F2/02

  Prostheses implantable into the body · CPC title