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Stable amorphous ticagrelor and a process for its preparation
US10017515B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10017515-B2 |
| Application number | US-201515503003-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 11, 2015 |
| Priority date | Aug 11, 2014 |
| Publication date | Jul 10, 2018 |
| Grant date | Jul 10, 2018 |
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Abstract
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The present invention relates to a stable amorphous ticagrelor and a process for its preparation.
First claim
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We claim: 1. A process for the preparation of a stable amorphous ticagrelor comprising: a) dissolving ticagrelor in a solvent selected from dichloromethane, tetrahydrofuran, and mixtures thereof to form a solution; and adding the solution of step a) to n-heptane to obtain the stable amorphous ticagrelor. 2. The process of claim 1 , wherein the stable amorphous ticagrelor shows no change in XRPD pattern when it is placed at a temperature of 25° C±2° C. at relative humidity of 60% ±5% for 1, 2, 3, and 6 months, and at a temperature of 5° C.±3° C. for 3 and 6 months. 3. The process of claim 1 , wherein the ticagrelor is dissolved in a solvent at a temperature of 40° C to 65° C. 4. The process of claim 3 , wherein the ticagrelor dissolved in the solvent is added to the n-heptane precooled to 0° C to 5° C. 5. The process of claim 4 , wherein the ticagrelor dissolved in the hydrocarbon solvent at a temperature of 0° C to 5° C is further stirred for about two hours to three hours to obtain a precipitate. 6. The process of claim 5 , wherein the precipitate is dried under vacuum at a temperature of 25° C to 35° C to obtain the amorphous ticagrelor.
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Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title
- C07D487/04Primary
Ortho-condensed systems · CPC title
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- What does patent US10017515B2 cover?
- The present invention relates to a stable amorphous ticagrelor and a process for its preparation.
- Who is the assignee on this patent?
- Sun Pharmaceutical Ind Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07D487/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).