Method for advancing non-magnetically responsive functional agent

Patent metadata

Field	Value
Publication number	US-10016765-B2
Application number	US-201715414039-A
Country	US
Kind code	B2
Filing date	Jan 24, 2017
Priority date	Oct 12, 2016
Publication date	Jul 10, 2018
Grant date	Jul 10, 2018

Abstract

A method for advancing a non-magnetically responsive functional agent includes steps (a) and (b). In step (a), a magnetically responsive agent construct at a target site is subjected to a homogeneous static magnetic field such that magnetically responsive micro particles are aligned to obtain a magnetic chain while the non-magnetically responsive functional agent is separated and discrete from the magnetic chain. In step (b), the magnetic chain is subjected to a rotational magnetic field to cause repeating breaking up and reformation of the magnetic chain such that the non-magnetically responsive functional agent is displaced to a predetermined position.

First claim

What is claimed is:

1. A method for advancing a non-magnetically responsive functional agent after a magnetically responsive agent construct is led to a target site in a liquid medium, the method comprising the steps of:
(a) subjecting the magnetically responsive agent construct at the target site to a homogeneous static magnetic field such that magnetically responsive micro particles of the magnetically responsive agent construct in the liquid medium are aligned to obtain a magnetic chain while the non-magnetically responsive functional agent is separated and discrete from the magnetic chain; and
(b) subjecting the magnetic chain to a rotational magnetic field to cause repeating breaking up and reformation of the magnetic chain such that in response to the repeating breaking up and reformation of the magnetic chain, the non-magnetically responsive functional agent is displaced to a predetermined position wherein the non-magnetically responsive functional agent is carried by and moved with the magnetically responsive agent construct before the magnetically responsive agent construct is let to the target site.

2. The method according to claim 1 , wherein each of the magnetically responsive micro particles includes a superparamagnetic material.

3. The method according to claim 1 , wherein the non-magnetically responsive functional agent is a treating agent for treating target cells within a body.

4. The method according to claim 1 , wherein two sinusoidal fields with 90 degrees phase shift are applied to generate the rotational magnetic field.

5. The method according to claim 4 , wherein each of the two sinusoidal fields has a frequency not less than 1 Hz, and a magnetic field strength ranging from 14 Oe to 20 Oe.

6. The method according to claim 1 , wherein, in step (b), Mason number is controlled to range from 0.012 to 0.03.

7. The method according to claim 1 , wherein the number of the magnetically responsive micro particles in the magnetic chain is not less than 5.

8. The method according to claim 1 , wherein the magnetically responsive micro particles have an average particle size ranging from 3 microns to 6 microns.

Assignees

• Univ National Chiao Tung

Inventors

• Chen Ching-Yao
• Li Yan-Hom
• Shiu Ren-Chiuan

Classifications

• B01L2400/043

  magnetic forces · CPC title

• A61M37/00 Primary

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title

• C02F1/48

  with magnetic or electric fields (C02F1/46 takes precedence) · CPC title

• B01L3/50273

  characterised by the means or forces applied to move the fluids · CPC title

• B03C2201/26

  for use in medical or biological applications · CPC title