Implant made of a biodegradable magnesium alloy

Patent metadata

Field	Value
Publication number	US-10016530-B2
Application number	US-201414535826-A
Country	US
Kind code	B2
Filing date	Nov 7, 2014
Priority date	Sep 30, 2008
Publication date	Jul 10, 2018
Grant date	Jul 10, 2018

Abstract

A vascular implant made in total or in parts of a biodegradable magnesium alloy consisting of Y: 2.0-6.0% by weight, Nd: 1.5-4.5% by weight, Gd: 0-4.0% by weight, Dy: 0-4.0% by weight, Er: 0-4.0% by weight, Zr: 0.1-1.0% by weight, Li: 0-0.2% by weight, Al: 0-0.3% by weight, under the condition that a) a total content of Er, Gd and Dy is in the range of 0.82-4.0% by weight and b) a total content of Nd, Er, Gd and Dy is in the range of 2.98-8.5% by weight, the balance being magnesium and incidental impurities up to a total of 0.3% by weight.

First claim

What is claimed is:

1. A vascular implant made in total or in parts of a biodegradable magnesium alloy consisting essentially of:
Y: 2.0-6.0% by weight,
Nd: 1.5-4.5% by weight,
Gd: 0-4.0% by weight,
Dy: 0-4.0% by weight,
Er: 0-4.0% by weight,
Zr: 0.1-1.0% by weight,
Li: 0-0.2% by weight,
Al: 0-0.3% by weight;
under the condition that:
a) a total content of Er, Gd and Dy is in the range of 0.82-4.0% by weight, and
b) a total content of Nd, Er, Gd and Dy is in the range of 2.98-8.5% by weight;
the balance being magnesium and incidental impurities up to a total of 0.3% by weight.

2. The vascular implant of claim 1 , wherein the content of Y is 3.5-4.5% by weight.

3. The vascular implant of claim 2 , wherein the content of Y is 3.9-4.1% by weight.

4. The vascular implant of claim 1 , wherein the content of Nd is 1.5-3.0% by weight.

5. The vascular implant of claim 1 , wherein the content of Nd is 2.0-3.0% by weight.

6. The vascular implant of claim 1 , wherein the content of Zr is 0.1-0.7% by weight.

7. The vascular implant of claim 1 , wherein the total content of Er, Gd and Dy is in the range of 0.82-1.5% by weight.

8. The vascular implant of claim 1 , wherein the total content of Nd, Er, Gd and Dy is in the range of 2.98-3.5% by weight.

9. The vascular implant of claim 1 , wherein the area percentage of particles in the alloy having an average particle size in the range of 1 to 15 μm is less than 3%.

10. The vascular implant of claim 1 , wherein the implant is a stent.

11. A method of manufacturing a vascular implant, comprising:
providing a biodegradable magnesium alloy consisting essentially of:
Y: 2.0-6.0% by weight,
Nd: 1.5-4.5% by weight,
Gd: 0-4.0% by weight,
Dy: 0-4.0% by weight,
Er: 0-4.0% by weight,
Zr: 0.1-1.0% by weight,
Li: 0-0.2% by weight,
Al: 0-0.3% by weight;
under the condition that:
a) a total content of Er, Gd and Dy is in the range of 0.82-4.0% by weight, and
b) a total content of Nd, Er, Gd and Dy is in the range of 2.98-8.5% by weight;
the balance being magnesium and incidental impurities; and

forming an implant up to a total of 0.3% by weight of the alloy.

12. The method of claim 11 , wherein the vascular implant is a stent.

Assignees

• Biotronik Ag

Inventors

• Gerold Bodo

Classifications

• C22C23/06

  with a rare earth metal as the next major constituent · CPC title

• A61L31/022 Primary

  Metals or alloys · CPC title

• C22F1/06

  of magnesium or alloys based thereon · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title