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Method for producing hydrogel, method for enveloping envelopment target, and method for releasing envelopment target
US10016506B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10016506-B2 |
| Application number | US-201515304675-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 16, 2015 |
| Priority date | Apr 17, 2014 |
| Publication date | Jul 10, 2018 |
| Grant date | Jul 10, 2018 |
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- Title
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Abstract
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Provided is a method for producing a hydrogel, which enables a hydrogel comprising polyethylene glycol to be produced under low peroxidase concentration conditions and physiological conditions. The method for producing a hydrogel involves crosslinking polyethylene glycol having two or more thiol groups using peroxidase in the presence of a phenol compound.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for producing a hydrogel, comprising: forming a mixture including a polyethylene glycol having two or more thiol groups and a phenol compound; and adding peroxidase to the mixture to crosslink the polyethylene glycol having two or more thiol groups, in presence of the phenol compound, and produce the hydrogel. 2. The method for producing a hydrogel according to claim 1 , wherein the peroxidase is a peroxidase derived from horseradish. 3. The method for producing a hydrogel according to claim 1 , wherein the phenol compound is at least one of tyramine hydrochloride, phenol, N-lycyl-L-tyrosine, hydroquinone, resorcinol, catechol and serotonin. 4. The method for producing a hydrogel according to claim 1 , wherein the polyethylene glycol having two or more thiol groups and a thiol compound having one or more thiol groups are crosslinked using the peroxidase in presence of the phenol compound. 5. The method for producing a hydrogel according to claim 1 , wherein the polyethylene glycol having two or more thiol groups and a phenol compound having one or more thiol groups are crosslinked using the peroxidase. 6. A method for enveloping an envelopment target, comprising: forming a mixture including a polyethylene glycol having two or more thiol groups and a phenol compound; and adding peroxidase to crosslink the polyethylene glycol having two or more thiol groups, in presence of the phenol compound, and produce a hydrogel to envelop the envelopment target in the hydrogel. 7. A method for releasing an envelopment target, comprising: (a) applying a reducing agent to dissolve a hydrogel enveloping an envelopment target, the hydrogel having been produced by forming a mixture including a polyethylene glycol having two or more thiol groups and a phenol compound, and adding peroxidase to crosslink the polyethylene glycol having two or more thiol groups, in presence of the phenol compound, and produce the hydrogel; and (b) releasing the envelopment target after the hydrogel is dissolved in (a).
Assignees
Inventors
Classifications
Compositions for preparing hydrogels · CPC title
Peroxidase (1.11.1.7), i.e. horseradish-peroxidase · CPC title
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34) · CPC title
Polysulfides · CPC title
Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title
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- What does patent US10016506B2 cover?
- Provided is a method for producing a hydrogel, which enables a hydrogel comprising polyethylene glycol to be produced under low peroxidase concentration conditions and physiological conditions. The method for producing a hydrogel involves crosslinking polyethylene glycol having two or more thiol groups using peroxidase in the presence of a phenol compound.
- Who is the assignee on this patent?
- Kamiya Noriho, Moriyama Kosuke, Hitachi Ltd, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K47/34. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).