Cellulose micropowder

Patent metadata

Field	Value
Publication number	US-10016367-B2
Application number	US-201515329804-A
Country	US
Kind code	B2
Filing date	Aug 3, 2015
Priority date	Aug 12, 2014
Publication date	Jul 10, 2018
Grant date	Jul 10, 2018

Abstract

The present invention relates to a cellulose powder usable for a satisfactory orally disintegrating tablet having excellent compression moldability and well-balanced tablet moldability and disintegration properties, which can obtain excellent ingestion feel without feeling roughness and dryness in the oral cavity, and more particularly to a cellulose powder with an average polymerization degree of 150 to 450, an average particle diameter of not less than 10 μm but less than 100 μm, and a primary particle ratio of 50% or more.

First claim

The invention claimed is:

1. A cellulose powder with an average polymerization degree of 150 to 450, an average particle diameter of not less than 10 μm but less than 100 μm, and a primary particle ratio of 50% or more and wherein particles of the cellulose powder have a ratio of major axis to minor axis (L/D) of 1.8 to 2.8.

2. The cellulose powder according to claim 1 , wherein a retention rate of polyethylene glycol with an average molecular weight of 400 is less than 190%, a tablet absorbing capacity at a tablet hardness of 60 N is 170% or less, and a tablet hardness at a tableting compression force of 2.0 kN is 130 N or more.

3. An orally disintegrating tablet comprising the cellulose powder of claim 1 .

4. A method for producing an orally disintegrating tablet comprising:
admixing 3 to 99% by mass of a cellulose powder as claimed in claim 1 , and 1 to 97% by mass of a component comprising: a drug or an active ingredient of a drug to obtain a mixture, and
compression molding the mixture.

5. The cellulose powder according to claim 1 , wherein a retention rate of polyethylene glycol with an average molecular weight of 400 is less than 180%, a tablet absorbing capacity at a tablet hardness of 60 N is not less than 50% but not more than 170%, and a tablet hardness at a tableting compression force of 2.0 kN is 150 N or more.

6. An orally disintegrating tablet comprising the cellulose powder of claim 2 .

7. An orally disintegrating tablet comprising the cellulose powder of claim 5 .

8. A method for producing an orally disintegrating tablet comprising:
admixing 3 to 99% by mass of a cellulose powder as claimed in claim 2 , and 1 to 97% by mass of a component comprising: a drug or an active ingredient of a drug to obtain a mixture, and
compression molding the mixture.

9. A method for producing an orally disintegrating tablet comprising:
admixing 3 to 99% by mass of a cellulose powder as claimed in claim 5 , and 1 to 97% by mass of a component comprising: a drug or an active ingredient of a drug to obtain a mixture and
compression molding the mixture.

10. The method for producing an orally disintegrating tablet according to claim 4 , wherein the component further comprises: an excipient, a binder, a disintegrant, or a lubricant.

11. The method for producing an orally disintegrating tablet according to claim 8 , wherein the component further comprises: an excipient, a binder, a disintegrant, or a lubricant.

12. The method for producing an orally disintegrating tablet according to claim 9 , wherein the component further comprises: an excipient, a binder, a disintegrant, or a lubricant.

Assignees

• Asahi Chemical Ind

Inventors

• Yoshida Naoya
• Ono Yasuhiko
• Obae Kazuhiro

Classifications

• A61K9/006

  Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays · CPC title

• A61K9/2095

  Tabletting processes · CPC title

• A61K31/7008

  Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine · CPC title

• A61K9/2059

  Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin · CPC title

• C08J3/12

  Powdering or granulating · CPC title