Treatment of atrial fibrillation using high-frequency pacing and ablation of renal nerves

Patent metadata

Field	Value
Publication number	US-10016233-B2
Application number	US-201113304933-A
Country	US
Kind code	B2
Filing date	Nov 28, 2011
Priority date	Dec 6, 2010
Publication date	Jul 10, 2018
Grant date	Jul 10, 2018

Abstract

A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating cardiac arrhythmias, particularly atrial fibrillation includes the insertion of an ablation catheter into the lumen of a renal artery. The ablation catheter is equipped with an electrode that can stimulate the wall tissue in the renal artery to help identify the location of a renal nerve. High-frequency stimulation of the renal nerve causes a decrease in the blood pressure of the patient thereby indicating that a renal nerve is nearby. The ablation catheter is used to ablate the renal nerve using radiofrequency, ultrasound, microwave energy or cryogenic cooling. An irrigated ablation catheter may be used to decrease damage to cells in the wall of the lumen of the renal artery other than the renal nerve, such as the endothelial cells.

First claim

What is claimed is:

1. A method for the treatment of a patient having a blood pressure comprising the steps of:
inserting an ablation catheter having an electrode mounted thereon into a renal artery of a patient wherein the renal artery has a wall defining a lumen;
stimulating a portion of the wall of the lumen of the renal artery using high-frequency pulses;
monitoring the blood pressure of the patient at least before and during, or at least before and after, stimulating a portion of the wall;
identifying a location on the wall of the lumen of the renal artery where the stimulation causes a decrease in the blood pressure of the patient thereby indicating the presence of a renal nerve near the location; and,
ablating the renal nerve near the identified location.

2. The method of claim 1 further comprising the steps of:
re-stimulating the identified location to determine whether the stimulation decreases the blood pressure of the patient;
re-ablating the identified location to ablate the renal nerve if there is a decrease in the blood pressure of the patient due to the re-stimulation; and,
repeating these steps until there is a lack of vagal response of the patient in response to the stimulation at the identified location.

3. A method of claim 1 wherein the ablation catheter is capable of ablating tissue using radiofrequency energy.

4. The method of claim 3 wherein the ablation catheter has an irrigated electrode.

5. The method of claim 1 wherein the ablation catheter is configured to ablate tissue using cryogenic cooling of the tissue.

6. The method of claim 1 wherein the ablation catheter is configured to ablate tissue using ultrasound.

7. The method of claim 1 wherein the ablation catheter is configured to ablate tissue using microwave radiation.

8. The method of claim 1 wherein the high-frequency stimulation is greater than or equal to 20 KHz.

9. The method of claim 4 wherein the irrigated electrode is configured to decrease damage to the endothelial cells lining the lumen of the renal artery.

10. The method of claim 4 wherein the irrigated electrode has a plurality of holes through which a cooling fluid is capable of flowing.

11. The method of claim 4 wherein the irrigated electrode is cooled by a cooling fluid in a closed system.

12. The method of claim 10 or 11 wherein the cooling fluid is saline.

13. The method of claim 10 or 11 wherein the cooling fluid is cooled below the body temperature of the patient.

14. The method of claim 13 wherein the cooling fluid is cooled below 20 degrees C.

15. The method of claim 1 wherein the treatment is for treating a cardiac arrhythmia.

16. The method of claim 15 further comprising the steps of:
inserting a second ablation catheter into the heart of a patient; and
ablating cardiac tissue using the ablation catheter in order to correct the cardiac arrhythmia.

17. The method of claim 16 wherein the cardiac arrhythmia is atrial fibrillation and the step of ablating cardiac tissue results in the isolation of one or more pulmonary veins.

18. The method of claim 1 wherein the ablation catheter is moved to a second location and the steps of stimulating, monitoring, identifying and ablating are repeated.

19. The method of claim 1 wherein the ablation catheter includes a location sensor.

20. The method of claim 1 wherein the location sensor is a magnetic location sensor capable of proving information with regard to the location of the tip of the ablation catheter.

21. A method for the treatment of a patient comprising the steps of:
inserting an irrigated ablation catheter having an electrode mounted thereon into a renal artery of a patient wherein the renal artery has a wall defining a lumen;
stimulating a portion of the wall of the lumen of the renal artery through the electrode using high-frequency pulses;
monitoring the blood pressure of the patient at least before and during, or at least before and after, stimulating a portion of the wall;
identifying a location on the wall of the lumen of the renal artery where the stimulation causes a decrease in the blood pressure of the patient thereby indicating the presence of a renal nerve near the location;
ablating the renal nerve near the identified location.

22. The method of claim 21 wherein the high-frequency stimulation is greater than or equal to 20 KHz.

23. The method of claim 21 wherein the irrigated electrode has a plurality of holes through which a cooling fluid is capable of flowing.

24. The method of claim 21 wherein the irrigated electrode is cooled by a cooling fluid.

25. The method of claim 24 wherein the cooling fluid is cooled substantially below the body temperature of the patient.

26. The method of claim 25 wherein the cooling fluid is cooled below 20 degrees C.

27. A method for locating a renal nerve in a renal artery of a patient having a blood pressure comprising the steps of:
inserting a catheter into the renal artery of the patient, wherein the renal artery has a wall defining a lumen, and the catheter had a stimulation element configured for stimulating a portion of the wall;
stimulating a portion of the wall of the lumen of the renal artery;
monitoring the blood pressure of the patient at least before and during, or at least before and after, stimulating a portion of the wall;
identifying a location on the wall of the lumen of the renal artery where the stimulation causes a decrease in the blood pressure of the patient thereby indicating the presence of a renal nerve near the location.

Assignees

• Pike Jr Robert W
• Biosense Webster Israel Ltd

Inventors

• Pike Jr Robert W

Classifications

• A61B18/1492 Primary

  having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence) · CPC title

• A61N1/36117

  for treating hypertension · CPC title

• A61B2018/00023

  closed, i.e. without wound contact by the fluid · CPC title

• A61B18/02

  by cooling, e.g. cryogenic techniques · CPC title

• A61N7/022

  intracavitary · CPC title