Method transfer between fluidic devices considering deviations from ideal behavior

Patent metadata

Field	Value
Publication number	US-10012624-B2
Application number	US-201615215233-A
Country	US
Kind code	B2
Filing date	Jul 20, 2016
Priority date	Sep 8, 2008
Publication date	Jul 3, 2018
Grant date	Jul 3, 2018

Abstract

An apparatus for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode representing a desired behavior of the first fluidic device and has a first real operation mode representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode representing a desired behavior of the second fluidic device and has a second real operation mode representing the actual behavior of the second fluidic device, the apparatus comprising a first determining unit configured for determining the first real operation mode based on the first target operation mode and based on a preknown parameterization of the first fluidic device, and a second determining unit configured for determining the second target operation mode based on the determined first real operation mode and based on a preknown parameterization of the second fluidic device.

First claim

The invention claimed is:

1. An apparatus that converts an operation for controlling a first fluidic device to a corresponding operation for controlling a second fluidic device, the apparatus comprising:
an input/output device programmed to receive a first target operation for treating a first fluid by the first fluidic device, wherein the first target operation defines a sequence of instructions for controlling the first fluidic device;
a database configured to store modeling parameters for the first and second fluidic devices; and
a processor programmed to:
receive the first target operation from the input/output device and receive the modeling parameters for the first and second fluidic devices from the database,
determine a real operation based on the first target operation and the modeling parameters of the first fluidic device, wherein the real operation represents actual behavior of treating the first fluid when controlling the first fluidic device with the first target operation,
determine a second target operation, for treating a second fluid by the second fluidic device, based upon the real operation and the modeling parameters of the second fluidic device, wherein the second target operation defines a sequence of instructions for controlling the second fluidic device; and
control the operation of the second fluidic device for treating the second fluid according to the determined second target operation, or transfer the determined second target operation to a data processing unit for controlling the operation of the second fluidic device for treating the second fluid according to the determined second target operation.

2. The apparatus of claim 1 , wherein the first target operation defines at least one of the group consisting of:
analyzing a medication,
analyzing a biological sample,
mixing various fluids,
performing diagnostics,
requiring official approval,
requiring official certification,
flushing the respective fluidic device,
selecting a solvent,
applying a concentration gradient, and
selecting an operation temperature.

3. The apparatus of claim 1 , wherein the modeling parameters of the first and second fluidic devices define physical properties of the respective first or second fluidic devices.

4. The apparatus of claim 3 , wherein the modeling parameters of each of the first and second fluidic devices define a physical property of a size of the respective first and second fluidic device, a volume of a fluid conduit of the respective first and second fluidic device, a pump performance of the respective first and second fluidic device, a delay parameter of operating the respective first and second fluidic device, a friction parameter indicative of friction occurring when operating the respective first and second fluidic device, a flush performance of the respective first and second fluidic device, and a combination or cooperation of different components of the respective first and second fluidic device.

5. The apparatus of claim 1 , wherein for determining the real operation, the processor is programmed to replace one of a straight curve section and an angled curve section of the first target operation with a rounded curve section.

6. The apparatus of claim 5 , wherein the processor is programmed to perform at least one of:
the substitution in accordance with a physical model of a process relating to the straight curve section or the angled curve section; and
the substitution by calculating a Bezier curve.

7. The apparatus of claim 1 , wherein the processor is programmed to perform at least one of:
modeling, based on physics, procedures taking place in the respective first and second fluidic devices, and/or based on a transfer function extracted empirically; and
simulating physical properties or procedures taking place in the respective first and second fluidic devices.

8. The apparatus of claim 1 , wherein the processor is further programmed to generate another real operation based upon the second target operation and the modeling parameters of the second fluidic device, wherein the other real operation represents actual behavior of treating the second fluid when controlling the second fluidic device with the second target operation.

9. The apparatus of claim 8 , wherein: the processor is further programmed to determine a difference between the real operation and the other real operation; and the input/output device is programmed to display the determined difference for qualifying the performance of operating the second fluidic device.

10. The apparatus of claim 1 , wherein the input/output device is further programmed to display at least a part of one or more of the first target operation, second target operation, and real operation on a display device.

11. The apparatus of claim 10 , wherein the input/output device is further programmed to perform at least one of: displaying the at least part of the first target operation, second target operation, or real operation as a graph; enabling a user to manipulate at least one of the first target operation, second target operation, and real operation; and updating at least another one of the first target operation, second target operation, and real operation upon manipulation of the at least one of the first target operation, second target operation, and real operation by the user.

12. The apparatus of claim 1 , wherein: the first fluidic device and the second fluidic device are one of the group consisting of fluid separation devices configured for separating compounds of a fluid, fluid purification devices, measurement devices, life science devices, sensor devices, devices for chemical, biological and/or pharmaceutical analysis, capillary electrophoresis devices, liquid chromatography devices, capillary electrochromatography devices, HPLC devices, gas chromatography devices and mass spectroscopy devices; the first fluidic device relates to a first product generation and the second fluidic device relates to a second product generation succeeding the first product generation; the first target operation, second target operation, and real operation are chromatographic methods; or the input/output device is programmed to display at least a part of one or more of the first target operation, second target operation, and real operation on a display device.

13. An apparatus that converts an operation for controlling a first fluidic device to a corresponding operation for controlling a second fluidic device, the apparatus comprising:
an input/output device programmed to receive a first target operation for treating a first fluid by the first fluidic device, wherein the first target operation defines a sequence of instructions for controlling the first fluidic device;
a database configured to store transfer functions representing the physical behaviors of the first and second fluidic devices; and
a processor programmed to:
receive the first target operation from the input/output device and receive the transfer functions for the first and second fluidic devices from the database,
determine a second target operation, for treating a second fluid by the second fluidic device, based upon the real operation and the modeling parameters of the second fluidic device, wherein the second target operation defines a sequence of instructions for controlling the second fluidic device; and
control the operation of the second fluidic device for treating the second fluid according to the determined second target operation, or transfer the determined second target operation to a data processing unit for controlling the operation of the second fluidic device for treating the second fluid according to

Assignees

• Agilent Technologies Inc

Inventors

• Witt Klaus
• Anderer Herbert
• Ritzmann Alwin
• Ruf Dominik

Classifications

• G01N30/8693

  Models, e.g. prediction of retention times, method development and validation · CPC title

• Y10T137/8376

  Combined · CPC title

• Y10T137/0318

  Processes · CPC title

• G01N30/86 Primary

  Signal analysis · CPC title

• F17D3/00

  Arrangements for supervising or controlling working operations · CPC title