Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders

Patent metadata

Field	Value
Publication number	US-10011612-B2
Application number	US-201615247399-A
Country	US
Kind code	B2
Filing date	Aug 25, 2016
Priority date	Aug 26, 2015
Publication date	Jul 3, 2018
Grant date	Jul 3, 2018

Abstract

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R 12 or R 13 on the A group is an aryl, heteroaryl or heterocycle (R 32 ) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.

First claim

We claim:

1. A compound of structure:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of structure:

or a pharmaceutically acceptable salt thereof; in a pharmaceutically acceptable carrier.

3. A compound of structure:

Assignees

• Achillion Pharmaceuticals Inc

Inventors

• Wiles Jason Allan
• Phadke Avinash S
• Deshpande Milind
• Agarwal Atul
• Chen Dawei
• Gadhachanda Venkat Rao
• Hashimoto Akihiro
• Pais Godwin
• Wang Qiuping
• Wang Xiangzhu

Classifications

• A61K31/40

  having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil · CPC title

• A61K31/395

  having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins · CPC title

• C07D493/04

  Ortho-condensed systems · CPC title

• A61P13/00

  Drugs for disorders of the urinary system · CPC title

• C07D495/04

  Ortho-condensed systems · CPC title