Anti-neurodegenerative natural compound isolated from alpiniae oxyphyllae fructose and their total synthesis
US-9475749-B2 · Oct 25, 2016 · US
Methods of treating Parkinson's disease
US10011555B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10011555-B2 |
| Application number | US-201715727638-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 9, 2017 |
| Priority date | Mar 14, 2013 |
| Publication date | Jul 3, 2018 |
| Grant date | Jul 3, 2018 |
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- Title
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Abstract
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This invention is directed to novel compounds isolated or derived from Alpiniae oxyphyllae fructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating Parkinson's disease in a patient, the method comprising: administering a compound to the patient to treat the Parkinson's disease, wherein the compound is selected from a group consisting of ((R)-4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid), ((S)-4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid) and (4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid). 2. The method of claim 1 , wherein the compound and chrysin are provided to the patient, and the compound and the chrysin exhibit a synergistic effect for treating the Parkinson's disease. 3. A method of protecting against neural damage in a subject in need thereof, the method comprising: administering a compound to the subject to protect against the neural damage, wherein the compound is selected from a group consisting of ((R)-4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid), ((S)-4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid) and (4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid). 4. The method of claim 3 , wherein the compound and chrysin are provided to the subject, and the compound and the chrysin exhibit a synergistic effect for protecting against the neural damage. 5. The method of claim 3 , wherein the compound protects against the neural damage in cerebellar granule neurons. 6. The method of claim 3 , wherein the compound protects against the neural damage in pheochromocytoma cells. 7. A method of protecting against neural cell loss in a subject in need thereof, the method comprising: administering a compound to the subject to protect against the neural cell loss, wherein the compound is selected from a group consisting of ((R)-4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid), ((S)-4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid) and (4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid). 8. The method of claim 7 , wherein the compound and chrysin are provided to the subject, and the compound and the chrysin exhibit a synergistic effect for protecting against the neural cell loss. 9. The method of claim 7 , wherein the compound protects against the neural cell loss in dopaminergic neurons.
Assignees
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Classifications
Anti-Parkinson drugs · CPC title
Drugs for disorders of the nervous system · CPC title
containing singly bound oxygen-containing groups · CPC title
containing six-membered aromatic rings and other rings · CPC title
- C07C59/52Primary
a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring · CPC title
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Frequently asked questions
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- What does patent US10011555B2 cover?
- This invention is directed to novel compounds isolated or derived from Alpiniae oxyphyllae fructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.
- Who is the assignee on this patent?
- Univ Macau
- What technology area does this patent fall under?
- Primary CPC classification C07C59/52. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 03 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).