Tricalcium phosphates, their composites, implants incorporating them, and methods for their production

Patent metadata

Field	Value
Publication number	US-10011486-B2
Application number	US-201615345155-A
Country	US
Kind code	B2
Filing date	Nov 7, 2016
Priority date	Aug 6, 2003
Publication date	Jul 3, 2018
Grant date	Jul 3, 2018

Abstract

Methods for the synthesis of tricalcium phosphates are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the tricalcium phosphate precursor precipitate. Particulate tricalcium phosphate compositions having an average crystal size of about 250 nm or less are provided. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.

First claim

What is claimed is:

1. A composition comprising particulate tricalcium phosphate (TCP) having an average particle size of about 5 μm or less and an average crystal size of about 250 nm or less, wherein the particulate TCP comprises α-TCP.

2. The composition of claim 1 , wherein the particulate TCP comprises pure α-TCP.

3. The composition of claim 1 , wherein the particulate TCP has an average crystal size of about 200 nm or less.

4. The composition of claim 1 , wherein the particulate TCP has an average crystal size of about 100 nm or less.

5. The composition of claim 1 , wherein when the particulate TCP is densified to form an article having a minimum dimension of about 0.5 cm or greater the article transmits about 50% or more light having a wavelength in the range of about 150 nm to about 1,000 nm.

6. The composition of claim 5 , wherein when the particulate TCP is densified to form an article having a minimum dimension of about 0.5 cm or greater the article transmits about 70% or more light having a wavelength in the range of about 150 nm to about 1,000 nm.

7. The composition of claim 1 , wherein when the particulate TCP is densified to form an article having a minimum dimension of about 0.5 cm or greater the article has a compressive strength of 150 MPa or greater.

8. The composition of claim 1 , wherein when the particulate TCP is densified to form an article having a minimum dimension of about 0.5 cm or greater the article has a density that is 90% of the theoretical density or greater.

9. A composition comprising particulate tricalcium phosphate (TCP) having an average particle size of about 5 m or less and an average crystal size of about 250 nm or less, wherein the particulate TCP comprises α-TCP, and wherein the TCP particles have an aspect ratio of about 1:1 to about 50:1.

10. The composition of claim 9 , wherein the TCP particles have an aspect ratio of about 3:1 or more.

11. The composition of claim 9 , wherein the particulate TCP comprises pure α-TCP.

12. The composition of claim 9 , wherein the particulate TCP has an average crystal size of about 200 nm or less.

13. The composition of claim 9 , wherein the particulate TCP has an average crystal size of about 100 nm or less.

14. The composition of claim 9 , wherein when the particulate TCP is densified to form an article having a minimum dimension of about 0.5 cm or greater the article transmits about 50% or more light having a wavelength in the range of about 150 nm to about 1,000 nm.

15. The composition of claim 14 , wherein when the particulate TCP is densified to form an article having a minimum dimension of about 0.5 cm or greater the article transmits about 70% or more light having a wavelength in the range of about 150 nm to about 1,000 run.

16. The composition of claim 9 , wherein when the particulate TCP is densified to form an article having a minimum dimension of about 0.5 cm or greater the article has a compressive strength of 150 MPa or greater.

17. The composition of claim 9 , wherein when the particulate TCP is densified to form an article having a minimum dimension of about 0.5 cm or greater the article has a density that is 90% of the theoretical density or greater.

18. A composition comprising particulate tricalcium phosphate (TCP) having an average particle size of about 5 μm or less, wherein the particulate TCP comprises α-TCP, and wherein when the particulate TCP is densified to form an article having a minimum dimension of about 0.5 cm or greater the article transmits about 50% or more light having a wavelength in the range of about 150 nm to about 1,000 nm.

19. The composition of claim 18 , wherein the particulate TCP comprises pure α-TCP.

20. The composition of claim 18 , wherein the TCP particles have an aspect ratio of about 3:1 or more.

Assignees

• Pioneer Surgical Tech Inc

Inventors

• Ahn Edward S

Classifications

• A61P19/08

  for bone diseases, e.g. rachitism, Paget's disease · CPC title

• C01B25/32 Primary

  Phosphates of magnesium, calcium, strontium, or barium · CPC title

• A61K33/42

  Phosphorus; Compounds thereof · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• C01P2006/60

  Optical properties, e.g. expressed in CIELAB-values · CPC title