Core-shell nanoparticles with multiple cores and a method for fabricating them

Patent metadata

Field	Value
Publication number	US-10006908-B2
Application number	US-201615099129-A
Country	US
Kind code	B2
Filing date	Apr 14, 2016
Priority date	Feb 20, 2007
Publication date	Jun 26, 2018
Grant date	Jun 26, 2018

Abstract

The present invention is directed toward core-shell nanoparticles, each comprising a ligand-capped metal shell surrounding a plurality of discrete, nonconcentric, metal-containing cores. Methods of making and using these nanoparticles are also disclosed.

First claim

What is claimed:

1. Core-shell nanoparticles, each core-shell nanoparticle comprising:
a silver shell;
a plurality of discrete, nonconcentric, iron oxide-containing cores, each core being within and surrounded by said silver shell; and
a ligand cap over said silver shell.

2. The core-shell nanoparticles according to claim 1 , wherein the nanoparticles are present in a monodispersion with controlled diameters ranging from 5 nm to 100 nm.

3. The core-shell nanoparticles according to claim 1 , wherein the iron oxide-containing cores are magnetic, paramagnetic, or superparamagnetic.

4. The core-shell nanoparticles according to claim 1 wherein the iron oxide-containing core comprises a compound selected from the group consisting of Fe 3 O 4 and Fe 2 O 3 .

5. The core-shell nanoparticles according to claim 4 , wherein the iron oxide-containing core comprises Fe 2 O 3 .

6. The core-shell nanoparticles according to claim 4 , wherein the iron oxide-containing core comprises Fe 3 O 4 .

7. The core-shell nanoparticles according to claim 1 , wherein the ligand cap is selected from the group consisting of decanethiolate, oleylamine, oleic acid, acrylates, N,N-trimethyl(undecylmercapto)ammonium (TUA), tetrabutylammonium tetrafluoroborate (TBA), tetramethylammonium bromide (TMA), cetyltrimethylammonium bromide (CTAB), citrates, poly methacrylate, ascorbic acid, DNA, 2-mercaptopropionic acid (MPA), 3-mercaptopropionic acid (MPA), 11-mercaptoundecanoic acid (MUA), 10-mercaptodecane-1-sulfonic acid, 16-mercaptohexadecanoicacid, diimide, N-(2-mercaptopropionyl)glycine (tiopronin), 2-mercaptoethanol, 4-mercapto-1-butanol, dodecyl sulfate, amino acids, homocysteine, homocystine, cysteine, cystine, glutathione, mercaptobenzoic acid (MBA), Protein A, bovine serum albumin (BSA), and anti-rabbit-IgG (Ab).

8. The core-shell nanoparticles according to claim 7 , wherein the ligand cap is selected from the group consisting of decanethiolate, oleylamine, and oleic acid.

9. The core-shell nanoparticles according to claim 8 , wherein the ligand cap is decanethiolate.

10. The core-shell nanoparticles according to claim 8 , wherein the ligand cap is oleylamine.

11. The core-shell nanoparticles according to claim 8 wherein the ligand cap is oleic acid.

12. The core-shell nanoparticles according to claim 1 , wherein the ligand cap is tetraoctylammonium bromide.

13. The core-shell nanoparticles according to claim 1 further comprising: a first binding material bound to the ligand-capped shell.

14. The core-shell nanoparticles according to claim 13 , wherein the first binding material is selected from the group consisting of proteins, peptides, antibodies, and antigens.

15. The core-shell nanoparticles according to claim 1 , wherein the iron oxide-containing core comprises Fe 3 O 4 and the ligand cap is tetraoctylammonium bromide.

Assignees

• Univ New York State Res Found

Inventors

• Zhong Chuan-Jian
• Park Hye-Young

Classifications

• B03C1/30

  Combinations with other devices, not otherwise provided for · CPC title

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• B01J13/02 Primary

  Making microcapsules or microballoons {(for medical preparations A61K9/50)} · CPC title

• G01N33/553

  Metal or metal coated · CPC title

• G01N33/54326

  Magnetic particles · CPC title