Controlled chemical release of hydrogen sulfide
US-9096504-B2 · Aug 4, 2015 · US
Compounds for pH-controlled release of hydrogen sulfide
US10005801B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10005801-B2 |
| Application number | US-201715447797-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 2, 2017 |
| Priority date | Mar 2, 2016 |
| Publication date | Jun 26, 2018 |
| Grant date | Jun 26, 2018 |
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- Title
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Abstract
Official abstract text for this publication.
The embodiments herein generally relates to compounds and methods for releasing H 2 S in a pH dependent manner. In particular, the invention provides compounds of various formulations which release H 2 S in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of H 2 S.
First claim
Opening claim text (preview).
We claim: 1. A compound having the formula wherein R1 is aryl, alkyl, aralkyl, and substituted aryl or a combination thereof; R2 is a hydrogen, or a part of a 3 to 7 membered ring system connecting R2 to R3; R3 is a hydrogen, or part of the 3 to 7 membered ring system connecting to R2 to R3, wherein the 3 to 7 membered ring system connecting R2 to R3, when present, is an optionally substituted, fully saturated or unsaturated, aromatic or a nonaromatic cyclic or hetrocyclic group; R4 is an alkyl or a carboxylic acid, or a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. 2. A compound of claim 1 , wherein R1 is phenyl, R2 and R3 is a heterocycle which is a 4 membered ring system, and R4 is a carboxylic acid.
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Classifications
Five-membered rings · CPC title
- C07F9/4419Primary
Amides of aromatic acids (P-C aromatic linkage) · CPC title
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US10005801B2 cover?
- The embodiments herein generally relates to compounds and methods for releasing H 2 S in a pH dependent manner. In particular, the invention provides compounds of various formulations which release H 2 S in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of H 2 S.
- Who is the assignee on this patent?
- Univ Washington State, The Board Of Supervisors Of Louisiana State Univ And Agricultural And Mechanical College
- What technology area does this patent fall under?
- Primary CPC classification C07F9/4419. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 26 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).