Compositions and methods for arranging colloid phases

Patent metadata

Field	Value
Publication number	US-10005058-B2
Application number	US-201514929131-A
Country	US
Kind code	B2
Filing date	Oct 30, 2015
Priority date	Oct 31, 2014
Publication date	Jun 26, 2018
Grant date	Jun 26, 2018

Abstract

The present invention generally relates to colloids and methods for changing the arrangement of droplet phases. In some embodiments, the colloids and methods comprise a plurality of droplets comprising two or more components, such that the two or more components can change arrangement of the components in the presence of an external stimulus. In some embodiments, the change in component arrangement is reversible. In certain embodiments, the change in component arrangement forms Janus droplets.

First claim

What is claimed:

1. A method of changing the arrangement of droplet phases, comprising:
providing a colloid comprising:
an outer phase; and
a plurality of droplets dispersed within the outer phase, wherein at least a portion of the plurality of droplets comprise a first component and a second component, the first component immiscible with the second component; and
stimulating the colloid, such that the first component and the second component change arrangement and such that the first component and the second component are immiscible with each other after changing arrangement.

2. The method of claim 1 , wherein the method comprises stimulating the colloid such that the first component and the second component transpose.

3. The method of claim 1 , wherein the method comprises stimulating the colloid such that a portion of the plurality of droplets form a Janus droplet comprising the first component and the second component.

4. The method of claim 1 , wherein stimulating the colloid comprises exposing the colloid to electromagnetic radiation, ionizing radiation, a magnetic field, an electric field, a mechanical force, or combinations thereof.

5. The method of claim 1 , wherein stimulating the colloid comprises adjusting the ionic strength of the colloid.

6. The method of claim 1 , wherein stimulating the colloid comprises adjusting the temperature of the colloid.

7. The method of claim 1 , wherein stimulating the colloid comprises exposing the colloid to photochemical stimulation.

8. The method of claim 1 , wherein stimulating the colloid comprises adding an analyte to the colloid.

9. The method of claim 8 , wherein the analyte comprises a biological compound, a drug, a macromolecule, a salt, an electrolyte, an enzyme, a nucleic acid, a carbohydrate, a peptide, a protein, a lipid, a phosphate, a sulfonate, a virus, a pathogen, an oxidant, a reductant, a toxin, a chemical warfare agent, an explosive, carbon dioxide, or combinations thereof.

10. The method of claim 8 , wherein the analyte comprises a surfactant.

11. The method of claim 1 , wherein the method comprises stimulating the colloid such at least one of the components changes conformation.

12. The method of claim 1 , wherein the method comprises stimulating the colloid such that the colloid releases at least one of the components.

13. The method of claim 1 , wherein the method comprises stimulating the colloid such that an average birefringence of the colloid changes.

14. The method of claim 1 , wherein the method comprises stimulating the colloid such that an average optical transmission of the colloid changes.

15. The method of claim 1 , wherein the method comprises stimulating the colloid such that a color of the colloid changes.

16. The method of claim 1 , wherein the method comprises stimulating the colloid such that an average luminescence of the colloid changes.

17. The method of claim 1 , wherein the first component and the second component are immiscible with one another before stimulating the colloid.

18. The method of claim 1 , wherein upon stimulating the colloid the first component and the second component become miscible with one another.

19. The method of claim 1 , wherein the method comprises, after the first component and the second component change arrangement, the first component and the second component are immiscible with one another.

20. The method of claim 1 , wherein the first component and the second component change arrangement reversibly.

21. A method of changing the arrangement of droplet phases, comprising:
providing a colloid comprising:
an outer phase; and
a plurality of droplets dispersed within the outer phase, wherein at least a portion of the plurality of droplets a first component and a second component, the first component immiscible with the second component; and

stimulating the colloid, such that the first component and the second component become miscible with each other; and
further stimulating the colloid, such that the first component and the second component become immiscible with each other.

22. A method of changing the arrangement of droplet phases, comprising:
providing a colloid comprising:
an outer phase; and
a plurality of droplets dispersed within the outer phase, wherein at least a portion of the plurality of droplets comprises a first component at least partially encapsulated by a second component immiscible with the first component; and

stimulating the colloid, such that the second component becomes at least partially encapsulated by the first component.

Assignees

• Massachusetts Inst Technology

Inventors

• Swager Timothy M
• Blankschtein Edmundo Daniel
• Zarzar Lauren Dell
• Sresht Vishnu
• Sletten Ellen
• Kalow Julia Ann

Classifications

• B01J13/0039 Primary

  Post treatment · CPC title

• Y10T428/2982

  Particulate matter [e.g., sphere, flake, etc.] · CPC title

• C12Q1/40

  involving amylase · CPC title

• B01F5/0085

  Operations & Transport · mapped topic

• Y10T428/2984

  Microcapsule with fluid core [includes liposome] · CPC title