Anticancer agent degradation method and anticancer agent degradation apparatus

Patent metadata

Field	Value
Publication number	US-10004932-B2
Application number	US-201414899024-A
Country	US
Kind code	B2
Filing date	Jun 18, 2014
Priority date	Jun 25, 2013
Publication date	Jun 26, 2018
Grant date	Jun 26, 2018

Abstract

There are provided an anticancer agent degradation method for protecting medical professionals from exposure to an anticancer agent externally scattered in, for example, a safety cabinet or prescription laboratory, during drug preparation or other circumstance, and an anticancer agent degradation apparatus for use with this anticancer agent degradation method. Anticancer agent flyoff in a safety cabinet, etc. is degraded by exploiting an action of ozone-containing air humidified by humidifying means. A relative humidity of humidified ozone-containing air is preferably greater than or equal to 80%. In controlling degradation treatment on the basis of CT values, a difference between expected humidity and measured humidity is reflected in an increment of CT value to understand the progress of anticancer agent degradation properly.

First claim

The invention claimed is:

1. An anticancer agent degradation method comprising:
obtaining a degree of ozone-induced degradation of an anticancer agent that varies with an increase in a CT value in an environment humidified by humidifying means as a function of relative humidity-said CT value in a degradation environment;
determining an assumed relative humidity in a degradation treatment of said anticancer agent and determining a CT setting as an indicator of degradation termination when said assumed relative humidity is maintained;
degrading said anticancer agent in a humidified environment;
in the degrading, repeatedly measuring a relative humidity of humidified ozone-containing air and an ozone concentration;
after every measurement of said relative humidity and said ozone concentration,
calculating a CT value increment as a product of a measured ozone concentration multiplied by a measurement time interval,
calculating a first degradation degree from said assumed relative humidity, said product, and a difference in said function,
calculating a second degradation degree from the measured relative humidity, said product, and a difference in said function, and
calculating a corrected CT value increment as a product of said CT value increment multiplied by a value obtained by dividing said second degradation degree by said first degradation degree; and

terminating said degrading of said anticancer agent by ozone when an integrated CT value of said corrected CT value increments at every measurement of said relative humidity and said ozone concentration reaches said CT setting.

Assignees

• Tamura Teco Co Ltd
• Univ Kinki

Inventors

• Tamura Kozo
• Fukuda Yoshiyuki
• Ishiwata Shunji
• Taga Atsushi

Classifications

• A62D3/38 Primary

  by oxidation; by combustion · CPC title

• A62D2101/26

  containing nitrogen or phosphorus · CPC title

• A62D2101/22

  containing halogen · CPC title

• A62D2101/28

  containing oxygen, sulfur, selenium or tellurium, i.e. chalcogen · CPC title