Propellant-free aerosol formulation for inhalation
US-2015306087-A1 · Oct 29, 2015 · US
US10004857B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10004857-B2 |
| Application number | US-201414453805-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 7, 2014 |
| Priority date | Aug 9, 2013 |
| Publication date | Jun 26, 2018 |
| Grant date | Jun 26, 2018 |
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A nebulizer is proposed which comprises a blocking device for blocking opening of the nebulizer in a tensioned state. The nebulizer comprises preferably an indicator device for indicating a tensioned state of the nebulizer. The nebulizer comprises further a depressible actuator member at a housing part which is detachable from the nebulizer.
Opening claim text (preview).
What is claimed is: 1. A nebulizer ( 1 ) for a fluid ( 2 ), comprising: a container ( 3 ) containing the fluid ( 2 ), wherein the container ( 3 ) is replaceable, a housing which opens for replacing the container ( 3 ), a delivery mechanism for dispensing the fluid ( 2 ), the delivery mechanism including a pressure generator ( 5 ) having a conveying element for conveying a metered dose of the fluid ( 2 ) from the container ( 3 ) into a pressure chamber ( 11 ), wherein the nebulizer ( 1 ) is in a loaded state when the dose of the fluid ( 2 ) is within the pressure chamber ( 11 ) and is ready to be placed under pressure and released from the pressure chamber ( 11 ) upon user activation for dispensing from the nebulizer ( 1 ), an indicator member ( 50 ) which shows numbers ( 52 ), symbols ( 53 ), or both, and which indicates a status, user instructions, or both, and a blocking device ( 68 ) adapted to block, when the nebulizer ( 1 ) is in the loaded state, stepwise movement or rotation of the indicator member ( 50 ), wherein the blocking device ( 68 ) comprises a blocking part ( 68 b ) that has different positions depending on whether the nebulizer ( 1 ) is in the loaded state or is in a discharged state, in which the dose of the fluid ( 2 ) has been released from the pressure chamber ( 11 ) and released from the nebulizer ( 1 ) upon the user activation, and wherein the blocking part ( 68 b ) of the blocking device ( 68 ) moves from a position of disengagement from the indicator member ( 50 ) when the nebulizer is in the discharged state to a position of engagement with the indicator member ( 50 ) when the nebulizer is placed into the loaded state, such that the blocking device ( 68 ) blocks stepwise movement or rotation of the indicator member ( 50 ) when in the loaded state. 2. The nebulizer according to claim 1 , characterized in that the nebulizer ( 1 ) is ready to dispense the dose of the fluid ( 2 ) in the loaded state automatically when actuating a stop element ( 8 ). 3. The nebulizer according to claim 1 , characterized in that the delivery mechanism comprises an energy store for pressurizing and/or dispensing the fluid ( 2 ). 4. The nebulizer according to claim 3 , characterized in that the energy store is a drive spring ( 7 ) tensioned in the loaded state of the nebulizer ( 1 ). 5. The nebulizer according to claim 1 , characterized in that the container ( 3 ) is moveable back and forth for delivering, pressurizing and/or dispensing the fluid ( 2 ). 6. The nebulizer according to claim 3 , characterized in that the container ( 3 ) is moveable back and forth within the nebulizer ( 1 ) or housing by the force of the energy store for pressurizing and/or nebulizing the fluid ( 2 ). 7. The nebulizer according to claim 1 , characterized in that the blocking device ( 68 ) blocks rotation of the indicator member ( 50 ) in the loaded state. 8. The nebulizer according to claim 7 , characterized in that the indicator member ( 50 ) locks the nebulizer or housing selectively against opening. 9. The nebulizer according to claim 7 , characterized in that the nebulizer comprises a counter device ( 23 ) with an actuation part ( 47 ) which, when a predetermined number of pressurizing or dispensing operations have been reached or exceeded with the container ( 3 ), cooperates with a guidance device ( 48 ) which comprises the indicator member ( 50 ). 10. The nebulizer according to claim 1 , characterized in that the blocking device ( 68 ) is driven, controlled or actuated by an axial position or movement of the container ( 3 ) within the housing and/or by an axial position or movement of a holder ( 6 ) holding the container ( 3 ) within the housing and/or by an axial position or movement of a drive spring ( 7 ). 11. The nebulizer according to claim 1 , characterized in that the blocking device ( 68 ) comprises a blocking element ( 68 a ) which comprises the blocking part ( 68 b ), wherein the blocking element ( 68 a ) coupled to a rotatable inner part ( 17 ) of the nebulizer ( 1 ) such that the blocking part ( 68 a ) moves axially in response to the rotatable inner part ( 17 ) such that the blocking part ( 68 b ) moves axially from the position of disengagement from the indicator member ( 50 ) when the nebulizer is in the discharged state to the position of engagement with the indicator member ( 50 ) when the nebulizer is placed into the loaded state, such that the blocking device ( 68 ) blocks stepwise movement or rotation of the indicator member ( 50 ) when in the loaded state. 12. The nebulizer according to claim 1 , characterized in that the housing is blocked against opening and/or container replacement until the container ( 3 ) has to be replaced due to multiple dispensing of fluid ( 2 ) and until the nebulizer ( 1 ) or an energy store has been released by dispensing fluid ( 2 ) or is in a non-tensioned state. 13. The nebulizer according to claim 1 , characterized in that the blocking is terminated automatically when an energy store is released upon actuation of a stop element ( 8 ) or after dispensing a dose of fluid ( 2 ). 14. The nebulizer ( 1 ) of claim 1 , wherein the nebulizer ( 1 ) is in a loaded state when a dose of the fluid ( 2 ) is in the pressure chamber ( 11 ), characterized in that the nebulizer ( 1 ) comprises an indicator device ( 73 ) for indicating when the nebulizer ( 1 ) is in the loaded state and when the nebulizer ( 1 ) is not in the loaded state. 15. The nebulizer according to claim 14 , characterized in that the indicator device ( 73 ) indicates optically whether the nebulizer ( 1 ) is in the loaded state. 16. The nebulizer according to claim 14 , characterized in that the indicator device ( 73 ) comprises a moveable or pivotable indicator element ( 74 ), whereina position of the indicator element ( 74 ) depends on the state of the nebulizer ( 1 ) or an energy store in form of a drive spring ( 7 ) which is comprised in the pressure generator ( 5 ). 17. The nebulizer ( 1 ) of claim 1 , wherein: the housing opens by detaching a housing part ( 18 ) from the nebulizer ( 1 ), the container ( 3 ) is inseparable from the housing part ( 18 ) and is replaceable by removing the housing part ( 18 ) from the nebulizer ( 1 ) and replacing with a new housing part ( 18 ) and associated new container ( 3 ), and the housing part ( 18 ) comprises a manually depressible actuator member ( 79 ) located therein, wherein the housing part ( 18 ) is detachable from the nebulizer ( 1 ) when the actuator member ( 79 ) is depressed and when the opening of the housing is not blocked. 18. The nebulizer according to claim 17 , characterized in that the nebulizer ( 1 ) comprises a retaining element ( 19 ) for reversibly locking the housing part ( 18 ) to an inner part ( 17 ) of the nebulizer ( 1 ), wherein the retaining element ( 19 ) is inseparable from the housing or inner part ( 17 ) and wherein the actuator member ( 79 ) is depressible for elastically deforming or flexing the retaining element ( 19 ) to allow detachment of the housing part ( 18 ). 19. The nebulizer according to claim 18 , characterized in that the pressure generator ( 5 ) includes a drive spring ( 7 ), and the retaining element ( 19 ) is blocked against deforming or flexing when the drive spring ( 7 ) is compressed and the nebulizer ( 1 ) is in the loaded state.
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