X-ray imaging contrast media with low iodine concentration and X-ray imaging process

Patent metadata

Field	Value
Publication number	US-10004816-B2
Application number	US-201314371350-A
Country	US
Kind code	B2
Filing date	Jan 10, 2013
Priority date	Jan 11, 2012
Publication date	Jun 26, 2018
Grant date	Jun 26, 2018

Abstract

The present invention relates to X-ray examinations and to the improvement of patient safety during such. More specifically the invention relates to X-ray diagnostic compositions having low concentrations of iodine and an optimized amount of electrolytes. The invention further relates to methods of X-ray examinations wherein a body is administered with an X-ray diagnostic composition comprising a low concentration of iodine and irradiated with a radiation dose.

First claim

What is claimed is:

1. An X-ray composition comprising Ioforminol and a pharmaceutically acceptable carrier or excipient, wherein the composition comprises an iodine concentration of 40-170 mg I/ml, a sodium ion concentration of 70-120 mM, a calcium ion concentration of 0.5-1.3 mM, and a ratio between the sodium ion and the calcium ion in the range between 110 and 120.

2. A composition as claimed in claim 1 , wherein the iodine concentration is 80-130 mg I/ml, a sodium ion concentration of 88-100 mM, and a calcium ion concentration of 0.7-0.9 mM.

3. A composition as claimed in claim 1 , further comprising potassium and/or magnesium ions.

4. A composition as claimed in claim 1 , wherein the total volume of the composition for administration to a living subject is between 1 and 250 ml.

5. A composition as claimed in claim 1 , wherein the iodine concentration is about 160 mg I/ml, the sodium concentration is about 82 mM, and having a calcium concentration of 0.7 mM.

6. A method of x-ray examination, the method comprising administering the composition of claim 1 to a living subject,
applying an X-ray radiation dose to the living subject,
examining the living subject with a diagnostic device and compiling data from the examination.

7. A method as claimed in claim 6 , wherein said dose of radiation has an average energy spectrum substantially corresponding to the k-edge of iodine.

8. A method as claimed in claim 6 , wherein the X-ray radiation dose is provided by a tube voltage energy in the range of 70-140 kVp.

9. A method as claimed in claim 6 , wherein the X-ray radiation dose is provided by a tube current in the range of 5-1000 mA.

10. A method as claimed in claim 6 , further including a step of noise reduction through an advanced image reconstruction method.

11. A method as claimed in claim 6 , wherein the noise reduction is selected from the iterative image reconstruction methods ASiR and MBIR.

12. A method as claimed in claim 6 , including Dual Energy CT.

13. A method of x-ray examination, the method comprising administering an X-ray composition to a living subject,
wherein the composition comprising Ioforminol having an iodine concentration of 80-130 mg I/ml, a sodium ion concentration of 88-100 mM, and a calcium ion concentration of 0.7-0.9 mM, a ratio between the sodium ion and the calcium ion in the range between 110 and 120, and a pharmaceutically acceptable carrier or excipient, the method comprising,
applying an X-ray radiation dose to the living subject,
examining the living subject with a diagnostic device and compiling data from the examination,
wherein said dose of radiation has an average energy spectrum substantially corresponding to the k-edge of iodine.

14. A method as claimed in claim 13 , wherein the X-ray radiation dose is provided by a tube voltage energy in the range of 70-140 kVp.

15. A method as claimed in claim 13 , wherein the X-ray radiation dose is provided by a tube current in the range of 5-500 mA.

16. A method as claimed in claim 13 , further including a step of noise reduction through an advanced image reconstruction method.

17. A method as claimed in claim 13 , wherein the noise reduction is selected from the iterative image reconstruction methods ASiR and MBIR.

18. A method as claimed in claim 13 , including Dual Energy CT.

19. A method as claimed in claim 13 , wherein the X-ray radiation dose is provided by a tube voltage energy in the range of about 80 kVp and the volume of the composition is about 1.5 mL/kg of the living subject.

Assignees

• Ge Healthcare As

Inventors

• Newton Ben
• Thaning Mikkel
• Veld Dirk-Jan In'T
• Langseth Karina
• Evans Paul Michael

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• A61K49/0438 Primary

  Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol · CPC title

• A61B6/032

  Transmission computed tomography [CT] · CPC title

• A61B6/481

  involving the use of contrast agents · CPC title

• A61K49/0433

  containing an organic halogenated X-ray contrast-enhancing agent · CPC title