Biomaterial handling device

Patent metadata

Field	Value
Publication number	US-10000730-B2
Application number	US-201514877969-A
Country	US
Kind code	B2
Filing date	Oct 8, 2015
Priority date	Feb 13, 2012
Publication date	Jun 19, 2018
Grant date	Jun 19, 2018

Abstract

A biomaterial handling device is described that will provide for functionality for performing both IVF procedures and washing techniques in a single device. Disclosed embodiments provide increased protection to biomaterial samples during processing and handling. Embodiments of the invention reduce labor intensive processes for both IVF and washing treatments and address reduced risks of contamination of biological samples by providing an increasingly sterile environment.

First claim

What is claimed is:

1. A biomaterial handling device comprising:
a main body portion comprising:
an internal receptacle;
a waste chamber connected to the internal receptacle, the waste chamber having a bottom surface having a plane;
at least one output port connected to the waste chamber at one end and terminating at an output port opening at another end on a surface of the main body portion; and
an insert having an inlet port opening at one end of the insert, wherein the inlet port opening has a plane and a wash chamber disposed within an interior of the insert,

wherein the inlet port opening allows access to the wash chamber,
wherein the wash chamber terminates into an opening at a bottom end of the insert,
wherein the insert is disposed within the internal receptacle,
wherein a longitudinal axis of the output port is configured at an acute angle from the plane of the bottom surface of the waste chamber.

2. The device of claim 1 , wherein the insert comprises a sealing ring around an exterior circumference of the insert, wherein the internal receptacle is sealed by the sealing ring.

3. The device of claim 1 , further comprising:
a removably attached lid connected to the main body portion for sealing the inlet port opening and the output port opening.

4. The device of claim 3 , wherein the lid includes separate seals for sealing the inlet port opening and the output port opening, respectively.

5. The device of claim 4 , wherein the seals comprise a material made from one of a thermoplastic elastomer and silicon.

6. The device of claim 4 , wherein one of the seals is a gas permeable moisture barrier.

7. The device of claim 6 , wherein the gas permeable moisture barrier is a membrane disposed in the lid.

8. The device of claim 7 , wherein the membrane is fixed to the lid.

9. The device of claim 6 , wherein the lid comprises an access port and the gas permeable moisture barrier is applied through the access port and over the inlet port opening.

10. The device of claim 9 , wherein the gas permeable moisture barrier is mineral oil.

11. The device of claim 9 , wherein the gas permeable moisture barrier forms a seal along edges of the access port.

12. The device of claim 9 , wherein the access port accommodates overflow of the gas permeable moisture barrier.

13. The device of claim 6 , wherein the gas permeable moisture barrier includes a high CO 2 permeable low water permeable material.

14. The device of claim 6 , wherein the gas permeable moisture barrier includes one of polymethylpentene (PMP), silicone and low density polyethylene (LDPE).

15. The device of claim 3 , wherein the lid is pivotably attached to the main body portion.

16. The device of claim 15 , wherein the main body portion comprises a locking portion and the lid comprises a flanged lip portion, wherein when closed, the flanged lip portion engages the locking portion of the main body portion in a snap-fitted arrangement to lock the lid to the main body portion.

17. The device of claim 3 , wherein the lid comprises a material made from one of polystyrene, polypropylene, and hi-density polyethylene.

18. The device of claim 1 , wherein the output port extends from the waste chamber such that the output port opening is fixed at a height between the inlet port opening and the connection of the waste chamber to the internal receptacle.

19. The device of claim 18 , wherein a level of media introduced into the wash chamber is maintained at a media volume within the wash chamber to never fall below the level of the wash chamber.

20. The device of claim 1 , wherein the main body portion comprises:
a gas permeable moisture barrier.

21. The device of claim 20 , wherein the gas permeable moisture barrier includes a high CO 2 permeability low water permeability material.

22. The device of claim 20 , wherein the gas permeable moisture barrier includes one of polymethylpentene (PMP), silicone and low density polyethylene (LDPE).

23. The device of claim 1 , wherein the insert and the main body portion comprise a material made from polystyrene.

24. The device of claim 1 , wherein the inlet port opening is generally oval in shape.

25. The device of claim 1 , further comprising a filter disposed at a bottom end of the insert, wherein the insert and filter are disposed within the internal receptacle.

26. The device of claim 25 , wherein the filter is attached to the insert by one of an ultrasonic weld or a thermal weld.

27. The device of claim 25 , wherein the filter comprises a mesh filter.

28. The device of claim 27 , wherein the mesh filter comprises a hole size in a range from approximately 30-500 microns.

29. The device of claim 27 , wherein the mesh filter comprises a material made from one of polyester, nylon, polystyrene, glass, high-density polyethylene (HDPE), polypropylene, and paper.

30. The device of claim 1 , further comprising a slot configured into one side of the main body portion and a key configured on an opposite side of the main body portion, wherein the key of one device attaches to the slot of another device.

31. The device of claim 30 , wherein multiple devices are attached to one another via respective keys and slots of the multiple devices to form an array of devices.

32. The device of claim 30 , wherein the slot comprises a female member and the key comprises a male member, wherein the male member is sized to correspond to attach to the female member in a secure fashion.

33. The device of claim 32 , wherein the female member and the male member are removably attached.

34. The device of claim 32 , wherein the female member and the male member are attached via interference fit arrangement.

35. The device of claim 32 , wherein the female member and the male member are attached via a snap-fit arrangement.

36. The device of claim 32 , wherein the female member comprises a slot configuration and the male member is attached to the female member by sliding into the slot configuration.

37. The device of claim 32 , wherein the female member comprises a key slot and the male member comprises a protrusion.

38. A biomaterial handling device comprising:
a main body portion comprising:
an internal receptacle;
a waste chamber connected to the internal receptacle, the waste chamber having a bottom surface having a plane;
at least one output port connected to the waste chamber at one end and terminating at an output port opening at another end on a surface of the main body portion; and
an insert having an inlet port opening at one end of the insert, wherein the inlet port opening has a plane and a wash chamber disposed within an interior of the insert,

wherein the inlet port opening allows access to the wash chamber,
wherein the wash chamber terminates into an opening at a bottom end of the insert,
wherein the insert is disposed within the internal receptacle,
wherein the inlet port opening plane and the output port opening plane are at an oblique angle relative to each other.

39. The device of claim 38 further comprising:
a removably attached lid connected to the main body portion for sealing the inlet port opening and the output port.

Assignees

• Jackson Lab

Inventors

• Malcolm Joan
• Byers Shannon
• Taft Robert A
• Sabin Paul C
• Zdeblick Andrew David
• Goryachev Ivan

Classifications

• C12M23/20

  Material Coatings (immunocoatings C12M25/00) · CPC title

• C12M23/38

  Caps; Covers; Plugs; Pouring means · CPC title

• C12M21/06 Primary

  for in vitro fertilization · CPC title

• C12M23/24

  Gas permeable parts · CPC title

• C12M37/04

  Seals · CPC title