Immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (CLL)

Patent metadata

Field	Value
Publication number	US-10000533-B2
Application number	US-201514743335-A
Country	US
Kind code	B2
Filing date	Jun 18, 2015
Priority date	Jun 20, 2014
Publication date	Jun 19, 2018
Grant date	Jun 19, 2018

Abstract

The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to several novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.

First claim

The invention claimed is:

1. A peptide of from 9 to 25 amino acids in length, comprising the amino acid sequence of SSSGLHPPK (SEQ ID NO: 77), wherein said peptide is in the form of a pharmaceutically acceptable salt, wherein said peptide is modified and/or includes non-peptide bonds.

2. A fusion protein, comprising the amino acid sequence of SSSGLHPPK (SEQ ID NO: 77); and N-terminal amino acids 1-80 of HLA-DR antigen-associated invariant chain (Ii).

3. A pharmaceutical composition comprising
(i) the peptide according to claim 1 , and
(ii) a pharmaceutically acceptable carrier.

4. The peptide of claim 1 consisting of the amino acid sequence of SSSGLHPPK (SEQ ID NO: 77).

Assignees

• Immatics Biotechnologies Gmbh

Inventors

• Stickel Juliane
• Kowalewski Daniel
• Rammensee Hans-Georg
• Stevanovic Stefan

Classifications

• G01N33/575

  for cancer · CPC title

• C07K14/70539

  MHC-molecules, e.g. HLA-molecules · CPC title

• C12Q1/6886

  for cancer (immunoassay for cancer G01N33/575) · CPC title

• C12Q2600/158

  Expression markers · CPC title

• A61P35/00

  Antineoplastic agents · CPC title