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US-9220793-B2 · Dec 29, 2015 · US
Stabilisation of radiopharmaceutical precursors
US10000518B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10000518-B2 |
| Application number | US-72156305-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 18, 2005 |
| Priority date | Dec 22, 2004 |
| Publication date | Jun 19, 2018 |
| Grant date | Jun 19, 2018 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-ß-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of storing 1,3,4,6-tetra-O-acetyl-2O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate), the method comprising dissolving mannose triflate in acetonitrile to form a solution and storing the solution in a sealed container for subsequent storage, wherein the solution consists of mannose triflate and acetonitrile, wherein the stability of the mannose triflate stored in the acetonitrile is better than the stability of mannose triflate stored without the acetonitrile, and wherein the acetonitrile has a water content between 100 ppm and 50000 ppm. 2. The method of claim 1 , wherein the concentration of the mannose triflate in the solution is between 10 mg/mL to 18 mg/mL. 3. The method of claim 1 , wherein the sealed container is a septum-sealed vial. 4. The method of claim 1 , wherein the acetonitrile has a water content of approximately 600 ppm. 5. The method of claim 1 , wherein the acetonitrile has a water content between 100 ppm and 600 ppm.
Assignees
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Classifications
to halogen · CPC title
- A61K51/0491Primary
Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers · CPC title
Processes for the preparation of sugar derivatives · CPC title
- C07H5/00Primary
Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium · CPC title
having the esterifying carboxyl radicals attached to acyclic carbon atoms · CPC title
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- What does patent US10000518B2 cover?
- The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-ß-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method co…
- Who is the assignee on this patent?
- Wickstrom Lill Torild, VELD Dirk Jan int, Osborn Nigel John, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification A61K51/0491. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).